DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_APCC_DBOX_1

Location: 852:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9429

ASA_SCORE: 84.8333

COIL: 0.5367

CONS_SCORE: 0.4046

DSS_SCORE: 0.5442

HELIX: 0.3959

FCONS_SCORE: 1.2014

RIG_SCORE: 0.7526

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A858S	DO229208	THCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.6477
p.S868P	DO218906	SKCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.5556
p.T861I	DO228960	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.3056
p.A849T	TCGA-S8-A6BV	ESCA	TCGA	ARNALTALF	DEG_APCC_DBOX_1	0.25
p.G849C	DO222769	COCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.25
p.R865C	TCGA-DF-A2KU	UCEC	TCGA	ARNALTALF	DEG_APCC_DBOX_1	0.1944
p.R865C	DO223286	UCEC	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.1944
p.R865H	ACH-000306	Non-Cancerous	CCLE	ARNALTALF	DEG_APCC_DBOX_1	0.1944
p.R847W	ACH-000995	Leukemia	CCLE	ARNALTALF	DEG_APCC_DBOX_1	0.1944
p.R846C	DO233737	GACA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.1667
p.K846R	DO222392	STAD	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.1667
p.T866A	DO223282	UCEC	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.1667
p.P867T	DO228985	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.1389
p.Q869K	DO228948	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0833
p.Q869K	DO229032	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0833
p.Q869K	DO229038	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0833
p.P869S	DO228960	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0833
p.Q869P	DO229234	THCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0833
p.P870T	DO228952	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0556
p.P870T	DO229025	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULV3	Cip1-interacting zinc finger protein	DEG_APCC_DBOX_1	852:860	ARNALTALF	APC,CDC20,FZR1	0.9429	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons