DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_ODPH_VHL_1

Location: 474:485

E3 ligase: VHL

DEGRON score: 0.5415

ASA_SCORE: 100.7583

COIL: 0.8973

CONS_SCORE: 0.231

DSS_SCORE: 0.4767

HELIX: 0.0242

FCONS_SCORE: 0.7354

RIG_SCORE: 0.7463

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G469D	DO234227	ESAD	ICGC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.1944
p.T479K	DO228952	LICA	ICGC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6195
p.A481V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00582	Pancreatic Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00608	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00572	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01040	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00367	Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00581	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00235	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00290	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00567	Other Solid Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00988	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01217	Other Blood Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00324	Neuroblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00359	Colorectal Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01551	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01781	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01336	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01575	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01378	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01782	Oral Cavity Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01662	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.P495L	SIDM01749	Osteosarcoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.0556
p.P465L	ACH-000340	Non-Cancerous	CCLE	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.0833
p.T491A	CAL-51	breast	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.1667
p.R491H	LN-405	central_nervous_system	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.1667
p.N464K	HCC2998	large_intestine	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.0556
p.N492K	HCC2998	large_intestine	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.1389
p.S476F	CAL-62	thyroid	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.7982
p.S476F	OVCAR-8	ovary	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.7982
p.R470H	LN-405	central_nervous_system	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEQTPVVVHV

Degron related mutations and impact score

Drug responses associated with CIZ1 mutations

All proteins holding degron of LAPEQTPVVVHV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULV3	Cip1-interacting zinc finger protein	DEG_ODPH_VHL_1	474:485	LAPEQTPVVVHV	VHL	0.5415	More...