DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_ODPH_VHL_1

Location: 474:485

E3 ligase: VHL

DEGRON score: 0.5415

ASA_SCORE: 100.7583

COIL: 0.8973

CONS_SCORE: 0.231

DSS_SCORE: 0.4767

HELIX: 0.0242

FCONS_SCORE: 0.7354

RIG_SCORE: 0.7463

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S476F	CAL-62	thyroid	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.7982
p.S476F	OVCAR-8	ovary	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.7982
p.A481V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00582	Pancreatic Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00608	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00572	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01040	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00367	Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00581	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00235	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00290	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00567	Other Solid Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00988	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01217	Other Blood Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00324	Neuroblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM00359	Colorectal Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01551	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01781	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01336	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01575	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936
p.A481V	SIDM01378	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	0.6936

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Drug responses associated with CIZ1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPEQTPVVVHV

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULV3	Cip1-interacting zinc finger protein	DEG_ODPH_VHL_1	474:485	LAPEQTPVVVHV	VHL	0.5415	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEQTPVVVHV

Degron related mutations and impact score

Drug responses associated with CIZ1 mutations

All proteins holding degron of LAPEQTPVVVHV