DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_SCF_FBW7_1

Location: 576:583

E3 ligase: FBXW7

DEGRON score: 0.9615

ASA_SCORE: 87.775

COIL: 0.9436

CONS_SCORE: 0.3478

DSS_SCORE: 0.5709

HELIX: 0.0306

FCONS_SCORE: 0.8878

RIG_SCORE: 0.6407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F593L	TCGA-A5-A2K5	UCEC	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	0.0556
p.R571H	TCGA-AA-3877	COAD	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	0.1944
p.R571H	TCGA-B5-A11E	UCEC	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	0.1944
p.R571H	DO7855	COAD	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	0.1944
p.R571H	DO41644	UCEC	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	0.1944
p.R571H	LN-405	central_nervous_system	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.1944
p.A574D	DO228948	LICA	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	0.2778
p.A581V	DO41199	UCEC	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	0.5825
p.Q568R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.1111
p.S577F	CAL-62	thyroid	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.6871
p.S577F	OVCAR-8	ovary	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.6871
p.R592W	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.0833
p.V581I	HCT-15	large_intestine	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.7076
p.V586I	HCT-15	large_intestine	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.25
p.R593P	H513	pleura	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.0556
p.H589N	WM793B	skin	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.1667
p.R574P	H513	pleura	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.2778
p.Q589R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SCF_FBW7_1	576:583	VSSTPAAT	FBXW7	0.9615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons