DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_SCF_SKP2-CKS1_1

Location: 872:879

E3 ligase: SKP2,CSK1

DEGRON score: 0.9873

ASA_SCORE: 108.075

COIL: 0.9239

CONS_SCORE: 0.3043

DSS_SCORE: 0.8687

HELIX: 0.0488

FCONS_SCORE: 1.1687

RIG_SCORE: 0.5942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R865C	TCGA-DF-A2KU	UCEC	TCGA	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R865C	DO223286	UCEC	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P877H	DO233935	GACA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.7694
p.Q869K	DO228948	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.Q869K	DO229032	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.Q869K	DO229038	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.P870T	DO228952	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P870T	DO229025	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P869S	DO228960	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.P867T	DO228985	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S868P	DO218906	SKCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.6667
p.V880G	DO229272	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.3056
p.Q869P	DO229234	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.Q873P	DO229234	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.5924
p.T866A	DO223282	UCEC	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A889V	SIDM01155	Glioma	GDSC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R865H	ACH-000306	Non-Cancerous	CCLE	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SCF_SKP2-CKS1_1	872:879	TQDKTPSK	SKP2,CSK1	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons