DegronMD

Uniprot ID: Q9ULV3

Source protein: Cip1-interacting zinc finger protein

Source gene: CIZ1

Class: DEG_SPOP_SBC_1

Location: 185:189

E3 ligase: SPOP

DEGRON score: 0.9422

ASA_SCORE: 103.82

COIL: 0.9658

CONS_SCORE: 0.3214

DSS_SCORE: 0.8562

HELIX: 0.0212

FCONS_SCORE: 0.9245

RIG_SCORE: 0.562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R179W	TCGA-AZ-6598	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1667
p.R179W	DO10276	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1667
p.R186W	TCGA-CM-6162	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.7523
p.R186W	DO8479	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7523
p.K196N	TCGA-D3-A2JC	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	0.25
p.S177L	TCGA-DR-A0ZM	CESC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1111
p.P193T	TCGA-EE-A2MK	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	0.2222
p.P193T	DO38177	SKCM	ICGC	ARTSS	DEG_SPOP_SBC_1	0.2222
p.R195Q	TCGA-SJ-A6ZI	UCEC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1667
p.R195Q	DO219784	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1667
p.S198Y	DO222798	COCA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.5278
p.D197N	DO50445	ESAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1111
p.S189F	DO222880	MELA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7982
p.R193Q	DO41871	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.2222
p.E184D	DO42400	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.M199I	SIDM01201	Other Blood Cancers	GDSC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.M199I	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.N175H	ACH-002397	Thyroid Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.0556
p.N175H	KMH-2	thyroid	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.E189Q	AN3-CA	endometrium	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.6744
p.P199H	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.E180Q	AN3-CA	endometrium	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.1944
p.P180H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons