DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ARTSS
Uniprot ID:
P49840
Source protein:
Glycogen synthase kinase-3 alpha
Source gene:
GSK3A
Class:
DEG_SPOP_SBC_1
Location:
17:21
E3 ligase:
SPOP
DEGRON score:
0.9986
ASA_SCORE:
79.58
COIL:
0.7648
CONS_SCORE:
0.2533
DSS_SCORE:
0.7402
HELIX:
0.0782
FCONS_SCORE:
1.1311
RIG_SCORE:
0.6374
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V22I
SK-UT-1
soft_tissue
COSMIC
ARTSS
DEG_SPOP_SBC_1
0.3056
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Drug responses associated with GSK3A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM00839
COREAD|large_intestine
p.G13fs*2 (Yes)
GDSC
CHIR-99021
5.037
SIDM00839
COREAD|large_intestine
p.G13fs*2 (Yes)
GDSC
SB216763
12.4859
SIDM00839
COREAD|large_intestine
p.G13fs*2 (Yes)
GDSC
CHIR-99021
23.5989
SIDM00839
COREAD|large_intestine
p.G13fs*2 (Yes)
GDSC
SB216763
50.56
SIDM00826
COREAD|large_intestine
p.F292L (No)
GDSC
CHIR-99021
5.6011
SIDM00826
COREAD|large_intestine
p.F292L (No)
GDSC
SB216763
58.6902
SIDM00826
COREAD|large_intestine
p.F292L (No)
GDSC
CHIR-99021
90.4119
SIDM00826
COREAD|large_intestine
p.F292L (No)
GDSC
SB216763
23.223
SIDM00216
COREAD|large_intestine
p.R272* (No)
GDSC
SB216763
57.37
SIDM00216
COREAD|large_intestine
p.V133M (No)
GDSC
SB216763
57.37
SIDM00789
COREAD|large_intestine
p.A118D (No)
GDSC
CHIR-99021
19.8132
SIDM00789
COREAD|large_intestine
p.A118D (No)
GDSC
SB216763
160.3627
SIDM00789
COREAD|large_intestine
p.A118D (No)
GDSC
CHIR-99021
141.9781
SIDM00789
COREAD|large_intestine
p.A118D (No)
GDSC
SB216763
92.626
SIDM00118
COREAD|large_intestine
p.F130V (No)
GDSC
CHIR-99021
13.1037
SIDM00118
COREAD|large_intestine
p.F130V (No)
GDSC
SB216763
113.6379
SIDM00118
COREAD|large_intestine
p.F130V (No)
GDSC
CHIR-99021
88.187
SIDM00118
COREAD|large_intestine
p.F130V (No)
GDSC
SB216763
209.26
SIDM00325
ESCA|oesophagus
p.I235M (No)
GDSC
CHIR-99021
21.8539
SIDM00325
ESCA|oesophagus
p.I235M (No)
GDSC
SB216763
142.369
SIDM00325
ESCA|oesophagus
p.I235M (No)
GDSC
CHIR-99021
102.9934
SIDM00112
KIRC|kidney
p.A378T (No)
GDSC
CHIR-99021
18.8907
SIDM00112
KIRC|kidney
p.A378T (No)
GDSC
SB216763
114.0497
SIDM00112
KIRC|kidney
p.A378T (No)
GDSC
CHIR-99021
2.4743
SIDM00951
LAML|acute_myeloid_leukaemia
p.R230H (No)
GDSC
CHIR-99021
4.2996
Showing 1 to 25 of 58 entries
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All proteins holding degron of ARTSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6RI45
Bromodomain and WD repeat-containing protein 3
DEG_SPOP_SBC_1
1489:1493
ARTSS
SPOP
0.9579
More...
Q9ULV3
Cip1-interacting zinc finger protein
DEG_SPOP_SBC_1
185:189
ARTSS
SPOP
0.9422
More...
Q9UKG1
DCC-interacting protein 13-alpha
DEG_SPOP_SBC_1
423:427
ARTSS
SPOP
0.9838
More...
P49840
Glycogen synthase kinase-3 alpha
DEG_SPOP_SBC_1
17:21
ARTSS
SPOP
0.9986
More...
O96028
Histone-lysine N-methyltransferase NSD2
DEG_SPOP_SBC_1
567:571
ARTSS
SPOP
0.9591
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2375:2379
ARTSS
SPOP
0.8756
More...
P48552
Nuclear receptor-interacting protein 1
DEG_SPOP_SBC_1
329:333
ARTSS
SPOP
0.9627
More...
Q5SQN1
Synaptosomal-associated protein 47
DEG_SPOP_SBC_1
359:363
ARTSS
SPOP
0.8489
More...
A1L170
Uncharacterized protein C1orf226
DEG_SPOP_SBC_1
254:258
ARTSS
SPOP
0.6742
More...
Showing 1 to 9 of 9 entries
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