DegronMD - Q9UKG1(APPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q692L	TCGA-17-Z022	LUAD	TCGA	VLSSS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.3056
p.S435C	TCGA-60-2698	LUSC	TCGA	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1111
p.S435C	DO26469	LUSC	ICGC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1111
p.P272H	TCGA-A5-A0G2	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1667
p.P272H	DO41235	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1667
p.R412Q	TCGA-A5-A1OF	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R412Q	DO42568	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R412Q	SIDM00530	Esophageal Carcinoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R412Q	SIDM00821	Kidney Carcinoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R412Q	ACH-001544	Esophageal Cancer	CCLE	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R412Q	KYAE-1	oesophagus	COSMIC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R275Q	TCGA-AA-3510	COAD	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.0833
p.R275Q	TCGA-EO-A3B0	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.0833
p.R275Q	DO7783	COAD	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.0833
p.R275Q	DO228935	COCA	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.0833
p.R275Q	DO219773	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.0833
p.L254F	TCGA-AP-A0LM	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.2222
p.L254F	DO43306	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.2222
p.R424Q	TCGA-AP-A1DV	UCEC	TCGA	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.6218
p.R424Q	DO43186	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.6218
p.R389Q	TCGA-AX-A1C5	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R389Q	DO229051	LICA	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.R389Q	DO41422	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.0833
p.E409K	TCGA-AX-A2HC	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1667
p.E409K	DO233898	GACA	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1667
p.E409K	DO41572	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1667
p.H408Y	TCGA-E6-A1LX	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1944
p.H408Y	DO41020	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1944
p.N274D	TCGA-EY-A2OM	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1111
p.N274D	DO43025	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1111
p.V398I	TCGA-FD-A43N	BLCA	TCGA	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation altering degron motif	0.5965
p.V398I	DO502	BLCA	ICGC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation altering degron motif	0.5965
p.P260L	TCGA-FS-A1ZC	SKCM	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation altering degron motif	0.6471
p.P260L	DO37487	SKCM	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation altering degron motif	0.6471
p.D259Y	TCGA-XR-A8TF	LIHC	TCGA	SDPLYVPDP	DEG_COP1_1	258:266	Mutation altering degron motif	0.7325
p.D259Y	DO223923	LIHC	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation altering degron motif	0.7325
p.G432R	DO222427	BTCA	ICGC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.S258N	DO10324	COAD	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation altering degron motif	0.818
p.E700G	DO234285	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.0833
p.E700G	DO231049	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	687:691	Mutation rewiring degron network	0.0833
p.D267N	DO233800	GACA	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.3056
p.D267Y	DO229009	LICA	ICGC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.3056
p.I251V	SIDM00103	Mesothelioma	GDSC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1389
p.I251V	ACH-002124	Lung Cancer	CCLE	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1389
p.I251V	H2373	pleura	COSMIC	SDPLYVPDP	DEG_COP1_1	258:266	Mutation rewiring degron network	0.1389
p.H408Q	SIDM00254	Neuroblastoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1944
p.H408Q	ACH-002283	Neuroblastoma	CCLE	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1944
p.H408Q	NB5	autonomic ganglia	COSMIC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation rewiring degron network	0.1944
p.P421L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2778
p.P421L	SIDM00685	Glioblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2778
p.P421L	SIDM01617	Endometrial Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2778
p.P421L	SIDM01664	Prostate Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2778
p.V398G	SIDM01012	Other Blood Cancers	GDSC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation altering degron motif	0.7532
p.V398G	ACH-000346	Leukemia	CCLE	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation altering degron motif	0.7532
p.V398G	JVM-3	haematopoietic and lymphoid tissue	COSMIC	VTPSPS	DEG_SCF_FBW7_1	398:403	Mutation altering degron motif	0.7532
p.R419Q	SIDM01658	Unknown	GDSC	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222
p.R419Q	ACH-000598	Myeloma	CCLE	ARTSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222

Kaplan plot for APPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APPL1

UniProt ID: Q9UKG1

Entrez ID: 26060

Protein name: DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APPL1 in