DegronMD

Uniprot ID: Q9UKG1

Source protein: DCC-interacting protein 13-alpha

Source gene: APPL1

Class: DEG_SPOP_SBC_1

Location: 423:427

E3 ligase: SPOP

DEGRON score: 0.9838

ASA_SCORE: 80.3

COIL: 0.7752

CONS_SCORE: 0.4688

DSS_SCORE: 0.7439

HELIX: 0.1128

FCONS_SCORE: 1.0149

RIG_SCORE: 0.5762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S435C	TCGA-60-2698	LUSC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1111
p.S435C	DO26469	LUSC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1111
p.R424Q	TCGA-AP-A1DV	UCEC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.6218
p.R424Q	DO43186	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.6218
p.G432R	DO222427	BTCA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1944
p.P421L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.P421L	SIDM00685	Glioblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.P421L	SIDM01617	Endometrial Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.P421L	SIDM01664	Prostate Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.R419Q	SIDM01658	Unknown	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2222
p.R419Q	ACH-000598	Myeloma	CCLE	ARTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons