DegronMD - Q6RI45(BRWD3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1285C	TCGA-22-4594	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.7541
p.S1285C	DO27476	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.7541
p.R1287K	TCGA-24-1844	OV	TCGA	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.2778
p.R1287K	DO30450	OV	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.2778
p.A1489S	TCGA-49-4514	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.7588
p.A1489S	DO23818	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.7588
p.Q1752H	TCGA-49-6761	LUAD	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.25
p.Q1752H	DO24566	LUAD	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.25
p.R1490M	TCGA-53-7624	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.7521
p.R1490M	DO25058	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.7521
p.H1488Y	TCGA-60-2698	LUSC	TCGA	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.3056
p.H1488Y	DO26469	LUSC	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.3056
p.A1503S	TCGA-64-5775	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.0556
p.A1503S	DO26025	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.0556
p.I1273S	TCGA-A5-A1OF	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.I1273S	DO42568	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1111
p.F1768V	TCGA-AA-3984	COAD	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1389
p.F1768V	DO9002	COAD	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1389
p.D1277N	TCGA-BS-A0UV	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.2222
p.D1277N	DO42793	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.2222
p.F1524L	TCGA-D3-A1Q7	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2778
p.F1524L	DO37981	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation rewiring degron network	0.2778
p.R1755M	TCGA-DU-6392	LGG	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation altering degron motif	0.8632
p.R1755M	DO22237	LGG	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation altering degron motif	0.8632
p.S1284L	TCGA-EE-A182	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.7667
p.S1284L	DO229456	SKCA	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.7667
p.S1284L	DO37814	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.7667
p.S1522L	TCGA-MU-A5YI	CESC	TCGA	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7667
p.S1522L	DO44346	CESC	ICGC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7667
p.S1522L	DO222395	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7667
p.S1493Y	TCGA-QG-A5YV	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.712
p.S1493Y	DO44088	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation altering degron motif	0.712
p.T1771A	DO227802	COCA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.0556
p.D1766H	DO223037	ESCA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1944
p.R1746Q	DO233624	GACA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.0833
p.R1746Q	SIDM02056	Pancreatic Carcinoma	GDSC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.0833
p.P1518T	DO229027	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7031
p.A1503D	DO229031	LICA	ICGC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.0556
p.P1518Q	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7035
p.P1518Q	ACH-000151	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7035
p.P1518Q	JM1	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	1518:1522	Mutation altering degron motif	0.7035
p.V1769M	SIDM01090	Colorectal Carcinoma	GDSC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1111
p.V1769M	ACH-000943	Colon/Colorectal Cancer	CCLE	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1111
p.V1769M	RKO	large intestine	COSMIC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.1111
p.Q1482H	SIDM00057	Neuroblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.Q1482H	ACH-000676	Brain Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.Q1482H	ACH-002389	Neuroblastoma	CCLE	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.Q1482H	ACN	autonomic ganglia	COSMIC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.S1500L	SIDM00560	Gastric Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.S1500L	ACH-000678	Gastric Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.S1500L	MKN7	stomach	COSMIC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.1389
p.V1486L	SIDM01561	Melanoma	GDSC	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.25
p.V1486L	ACH-000799	Skin Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	1489:1493	Mutation rewiring degron network	0.25
p.R1754W	ACH-000586	Lung Cancer	CCLE	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.3056
p.R1754W	NCI-H1876	lung	COSMIC	RTVLYND	LIG_APCC_ABBAyCdc20_2	1755:1761	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRWD3

UniProt ID: Q6RI45

Entrez ID: 254065

Protein name: Bromodomain and WD repeat-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRWD3 in