DegronMD

Uniprot ID: Q6RI45

Source protein: Bromodomain and WD repeat-containing protein 3

Source gene: BRWD3

Class: DEG_SPOP_SBC_1

Location: 1281:1285

E3 ligase: SPOP

DEGRON score: 0.8916

ASA_SCORE: 74.2

COIL: 0.9168

CONS_SCORE: 0.3232

DSS_SCORE: 0.5053

HELIX: 0.0662

FCONS_SCORE: 1.1377

RIG_SCORE: 0.5678

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1284L	TCGA-EE-A182	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.7667
p.S1284L	DO229456	SKCA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7667
p.S1284L	DO37814	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7667
p.S1285C	TCGA-22-4594	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.7541
p.S1285C	DO27476	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7541
p.R1287K	TCGA-24-1844	OV	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R1287K	DO30450	OV	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.D1277N	TCGA-BS-A0UV	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2222
p.D1277N	DO42793	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.I1273S	TCGA-A5-A1OF	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1111
p.I1273S	DO42568	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 11 of 11 entries

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Drug responses associated with BRWD3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SPOP_SBC_1	626:630	PGTSS	SPOP	0.9994	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	870:874	PGTSS	SPOP	0.9993	More...
Q53H80	Akirin-2	DEG_SPOP_SBC_1	126:130	PGTSS	SPOP	0.9884	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1281:1285	PGTSS	SPOP	0.8916	More...
P29400	Collagen alpha-5	DEG_SPOP_SBC_1	1453:1457	PGTSS	SPOP	0.8142	More...
P09871	Complement C1s subcomponent	DEG_SPOP_SBC_1	551:555	PGTSS	SPOP	0.8928	More...
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SPOP_SBC_1	226:230	PGTSS	SPOP	0.824	More...
Q96IM9	DPY30 domain-containing protein 2	DEG_SPOP_SBC_1	123:127	PGTSS	SPOP	0.9785	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	683:687	PGTSS	SPOP	0.9947	More...
Q96PY5	Formin-like protein 2	DEG_SPOP_SBC_1	598:602	PGTSS	SPOP	0.9832	More...
Q6IPT2	Golgi associated RAB2 interactor protein 5A	DEG_SPOP_SBC_1	15:19	PGTSS	SPOP	0.9651	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	296:300	PGTSS	SPOP	0.9951	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	963:967	PGTSS	SPOP	0.9939	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	599:603	PGTSS	SPOP	0.5271	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	418:422	PGTSS	SPOP	0.9951	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	662:666	PGTSS	SPOP	0.9973	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7738:7742	PGTSS	SPOP	0.9963	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8317:8321	PGTSS	SPOP	0.9624	More...
Q96RE7	Nucleus accumbens-associated protein 1	DEG_SPOP_SBC_1	264:268	PGTSS	SPOP	0.9975	More...
Q8NGY2	Olfactory receptor 6K2	DEG_SPOP_SBC_1	317:321	PGTSS	SPOP	0.8496	More...
Q96G74	OTU domain-containing protein 5	DEG_SPOP_SBC_1	493:497	PGTSS	SPOP	0.9984	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	372:376	PGTSS	SPOP	0.9983	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	467:471	PGTSS	SPOP	0.9991	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	7:11	PGTSS	SPOP	0.7536	More...
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_SPOP_SBC_1	833:837	PGTSS	SPOP	0.9931	More...

Showing 1 to 25 of 34 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTSS

Degron related mutations and impact score

Drug responses associated with BRWD3 mutations

All proteins holding degron of PGTSS