DegronMD - P29400(COL4A5)

FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

GO - Biological processes (BP): collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]

GO - Molecular function (MF): extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]

GO - Cellular component (CC): basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; collagen type IV trimer [GO:0005587]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromuscular junction [GO:00... View more >>

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
GRTGLDGLP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Collagen alpha-5	787:795	More..
GRPGLNGMK	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Collagen alpha-5	1312:1320	More..
PGTSS	DEG_SPOP_SBC_1	SPOP	Collagen alpha-5	1453:1457	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1319L	TCGA-EE-A2M7	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R1319L	TCGA-MP-A4TE	LUAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R788L	DO229032	LICA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8428
p.R1313L	DO45410	LUAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R1313L	DO37847	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R788C	DO218223	GACA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8301
p.R788H	TCGA-BT-A20N	BLCA	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8244
p.R788H	DO550	BLCA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8244
p.Q1314H	TCGA-AD-6889	COAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7582
p.Q1314H	DO8463	COAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7582
p.R1319Q	DO227587	COCA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7329
p.L1313F	SIDM01086	B-Lymphoblastic Leukemia	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.L1313F	ACH-000874	Leukemia	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.L1313F	RS4-11	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.P1320S	DO50970	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SIDM00381	Cervical Carcinoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SIDM01726	Ewing's Sarcoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SKG-IIIa	cervix	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1453S	DO219481	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6752
p.P795H	TCGA-BF-A1Q0	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583

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Kaplan plot for COL4A5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A5

UniProt ID: P29400

Entrez ID: 1287

Protein name: Collagen alpha-5(IV) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A5 in