DegronMD - P29400(COL4A5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P782L	TCGA-2W-A8YY	CESC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.1944
p.P782L	DO223732	CESC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.1944
p.P1447S	TCGA-86-8279	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.1667
p.P1311L	TCGA-AC-A23H	BRCA	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.3056
p.P1311L	DO2401	BRCA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.3056
p.Q1314H	TCGA-AD-6889	COAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7582
p.Q1314H	DO8463	COAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7582
p.G805E	TCGA-AP-A051	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.G805E	DO42673	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.P786L	TCGA-AP-A0LS	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.3056
p.P786L	DO43178	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.3056
p.R777C	TCGA-AP-A1E0	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	TCGA-EE-A3AH	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	TCGA-EO-A22U	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	DO222635	MELA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	DO37443	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	DO43154	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777C	DO43755	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.H1466Y	TCGA-AX-A0J1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.0833
p.P795H	TCGA-BF-A1Q0	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583
p.P795H	DO47374	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583
p.P795H	SIDM00282	Colorectal Carcinoma	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583
p.P795H	ACH-000998	Colon/Colorectal Cancer	CCLE	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583
p.P795H	CW-2	large intestine	COSMIC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6583
p.R788H	TCGA-BT-A20N	BLCA	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8244
p.R788H	DO550	BLCA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8244
p.G1315C	TCGA-D9-A1X3	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6489
p.G1315C	DO37456	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6489
p.M1325I	TCGA-DA-A1I8	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1944
p.P1459S	TCGA-DA-A95Z	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.2778
p.G1303C	TCGA-EE-A20F	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.R1319L	TCGA-EE-A2M7	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R1319L	TCGA-MP-A4TE	LUAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.P785L	TCGA-ER-A19D	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.2778
p.P785L	DO37750	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.2778
p.G799S	TCGA-ER-A19D	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.2222
p.G799S	DO37750	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.2222
p.P1329T	TCGA-FA-A4BB	DLBC	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.P1329S	TCGA-FW-A3R5	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.P1329S	DO222868	MELA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.P1329S	DO37406	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.P1329S	SAS	upper aerodigestive tract	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.P795L	TCGA-W3-AA1V	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6471
p.P795L	DO51276	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6471
p.P1450A	DO225049	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.25
p.G1451S	DO51976	CLLE	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.2778
p.R1319Q	DO227587	COCA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.7329
p.P1323T	DO219885	DLBC	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.25
p.R788C	DO218223	GACA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8301
p.G787R	DO233650	GACA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6457
p.P1326S	DO49058	HNSC	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1667
p.G790V	DO228985	LICA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.6421
p.G1303V	DO229022	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0833
p.R788L	DO229032	LICA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation altering degron motif	0.8428
p.K1326E	DO50890	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1667
p.P1320S	DO50970	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SIDM00381	Cervical Carcinoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SIDM01726	Ewing's Sarcoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.P1320S	SKG-IIIa	cervix	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6752
p.R1313L	DO45410	LUAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.R1313L	DO37847	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.8428
p.G1330A	DO32708	OV	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0556
p.R1466C	DO32487	OV	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.0833
p.R1466C	DO41847	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.0833
p.P786Q	DO218862	SKCA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.3056
p.M1319I	DO37424	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6507
p.P1453S	DO219481	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6752
p.H1460Y	DO41199	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.25
p.F779C	SIDM02041	Colorectal Carcinoma	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.1111
p.N1323S	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.25
p.N1323S	ACH-000226	Lymphoma	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.25
p.N1323S	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.25
p.Q1308R	SIDM00935	Other Solid Cancers	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.2222
p.Q1308R	ACH-002091	Skin Cancer	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.2222
p.Q1308R	CAL-39	vulva	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.2222
p.G1454R	SIDM00057	Neuroblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6457
p.G1454R	SIDM00552	Rhabdomyosarcoma	GDSC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6457
p.G1454R	ACH-000607	Rhabdoid	CCLE	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6457
p.G1454R	KYM-1	soft tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation altering degron motif	0.6457
p.R777H	SIDM00211	B-Lymphoblastic Leukemia	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777H	ACH-002209	Leukemia	CCLE	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.R777H	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	GRTGLDGLP	DEG_APCC_DBOX_1	787:795	Mutation rewiring degron network	0.0556
p.P1302S	SIDM00217	Colorectal Carcinoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0556
p.P1302S	ACH-000999	Colon/Colorectal Cancer	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0556
p.P1302S	SNU-1040	large intestine	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0556
p.L1313F	SIDM01086	B-Lymphoblastic Leukemia	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.L1313F	ACH-000874	Leukemia	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.L1313F	RS4-11	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.6981
p.P1326L	ACH-001203	Lymphoma	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1667
p.P1326L	639-V	urinary tract	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1667
p.P1326L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1667
p.G1448R	KYM-1	soft tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	1453:1457	Mutation rewiring degron network	0.1944
p.L1307F	RS4-11	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.1944
p.P1314S	SKG-IIIa	cervix	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.5641
p.Q1302R	CAL-39	vulva	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation rewiring degron network	0.0556
p.N1317S	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	1312:1320	Mutation altering degron motif	0.5958

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A5

UniProt ID: P29400

Entrez ID: 1287

Protein name: Collagen alpha-5(IV) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A5 in