DegronMD

Uniprot ID: P29400

Source protein: Collagen alpha-5

Source gene: COL4A5

Class: DEG_APCC_DBOX_1

Location: 787:795

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.919

ASA_SCORE: 72.9889

COIL: 0.9206

CONS_SCORE: 0.6388

DSS_SCORE: 0.8498

HELIX: 0.0153

FCONS_SCORE: 0.9489

RIG_SCORE: 0.5527

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P782L	TCGA-2W-A8YY	CESC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.1944
p.P782L	DO223732	CESC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.1944
p.G805E	TCGA-AP-A051	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.G805E	DO42673	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.P786L	TCGA-AP-A0LS	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.3056
p.P786L	DO43178	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.3056
p.R777C	TCGA-AP-A1E0	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	TCGA-EE-A3AH	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	TCGA-EO-A22U	UCEC	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	DO222635	MELA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	DO37443	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	DO43154	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777C	DO43755	UCEC	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.P795H	TCGA-BF-A1Q0	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.6583
p.P795H	DO47374	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6583
p.P795H	SIDM00282	Colorectal Carcinoma	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6583
p.P795H	ACH-000998	Colon/Colorectal Cancer	CCLE	GRTGLDGLP	DEG_APCC_DBOX_1	0.6583
p.P795H	CW-2	large_intestine	COSMIC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6583
p.R788H	TCGA-BT-A20N	BLCA	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.8244
p.R788H	DO550	BLCA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.8244
p.P785L	TCGA-ER-A19D	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.2778
p.P785L	DO37750	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.2778
p.G799S	TCGA-ER-A19D	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.2222
p.G799S	DO37750	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.2222
p.P795L	TCGA-W3-AA1V	SKCM	TCGA	GRTGLDGLP	DEG_APCC_DBOX_1	0.6471
p.P795L	DO51276	SKCM	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6471
p.R788C	DO218223	GACA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.8301
p.G787R	DO233650	GACA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6457
p.G790V	DO228985	LICA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.6421
p.R788L	DO229032	LICA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.8428
p.P786Q	DO218862	SKCA	ICGC	GRTGLDGLP	DEG_APCC_DBOX_1	0.3056
p.F779C	SIDM02041	Colorectal Carcinoma	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	0.1111
p.R777H	SIDM00211	B-Lymphoblastic Leukemia	GDSC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777H	ACH-002209	Leukemia	CCLE	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556
p.R777H	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	GRTGLDGLP	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRTGLDGLP

Degron related mutations and impact score

Drug responses associated with COL4A5 mutations

All proteins holding degron of GRTGLDGLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29400	Collagen alpha-5	DEG_APCC_DBOX_1	787:795	GRTGLDGLP	APC,CDC20,FZR1	0.919	More...