DegronMD

Uniprot ID: P29400

Source protein: Collagen alpha-5

Source gene: COL4A5

Class: DEG_APCC_DBOX_1

Location: 1312:1320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7417

ASA_SCORE: 84.2667

COIL: 0.9544

CONS_SCORE: 0.6043

DSS_SCORE: 0.7979

HELIX: 0.0129

FCONS_SCORE: 0.9595

RIG_SCORE: 0.5658

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1311L	TCGA-AC-A23H	BRCA	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.3056
p.P1311L	DO2401	BRCA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.3056
p.Q1314H	TCGA-AD-6889	COAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.7582
p.Q1314H	DO8463	COAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.7582
p.G1315C	TCGA-D9-A1X3	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.6489
p.G1315C	DO37456	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6489
p.M1325I	TCGA-DA-A1I8	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.1944
p.G1303C	TCGA-EE-A20F	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.R1319L	TCGA-EE-A2M7	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.8428
p.R1319L	TCGA-MP-A4TE	LUAD	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.8428
p.P1329T	TCGA-FA-A4BB	DLBC	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.P1329S	TCGA-FW-A3R5	SKCM	TCGA	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.P1329S	DO222868	MELA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.P1329S	DO37406	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.P1329S	SAS	upper_aerodigestive_tract	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.R1319Q	DO227587	COCA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.7329
p.P1323T	DO219885	DLBC	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.25
p.P1326S	DO49058	HNSC	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.1667
p.G1303V	DO229022	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0833
p.K1326E	DO50890	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.1667
p.P1320S	DO50970	LICA	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6752
p.P1320S	SIDM00381	Cervical Carcinoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6752
p.P1320S	SIDM01726	Ewing's Sarcoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6752
p.P1320S	SKG-IIIa	cervix	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6752
p.R1313L	DO45410	LUAD	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.8428
p.R1313L	DO37847	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.8428
p.G1330A	DO32708	OV	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0556
p.M1319I	DO37424	SKCM	ICGC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6507
p.N1323S	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.25
p.N1323S	ACH-000226	Lymphoma	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	0.25
p.N1323S	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.25
p.Q1308R	SIDM00935	Other Solid Cancers	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.2222
p.Q1308R	ACH-002091	Skin Cancer	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	0.2222
p.Q1308R	CAL-39	vulva	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.2222
p.P1302S	SIDM00217	Colorectal Carcinoma	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0556
p.P1302S	ACH-000999	Colon/Colorectal Cancer	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	0.0556
p.P1302S	SNU-1040	large_intestine	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0556
p.L1313F	SIDM01086	B-Lymphoblastic Leukemia	GDSC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6981
p.L1313F	ACH-000874	Leukemia	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	0.6981
p.L1313F	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.6981
p.P1326L	ACH-001203	Lymphoma	CCLE	GRPGLNGMK	DEG_APCC_DBOX_1	0.1667
p.P1326L	639-V	urinary_tract	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.1667
p.P1326L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.1667
p.L1307F	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.1944
p.P1314S	SKG-IIIa	cervix	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.5641
p.Q1302R	CAL-39	vulva	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.0556
p.N1317S	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLNGMK	DEG_APCC_DBOX_1	0.5958

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPGLNGMK

Degron related mutations and impact score

Drug responses associated with COL4A5 mutations

All proteins holding degron of GRPGLNGMK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29400	Collagen alpha-5	DEG_APCC_DBOX_1	1312:1320	GRPGLNGMK	APC,CDC20,FZR1	0.7417	More...