DegronMD - Q96IM9(DYDC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P137A	TCGA-35-3615	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0556
p.T113M	TCGA-BR-6452	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0556
p.F118C	TCGA-BR-8360	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation substituting flanking lysine	0.3056
p.E121K	TCGA-CV-7180	HNSC	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.A130V	TCGA-D1-A1O7	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.25
p.L131V	TCGA-FI-A2D0	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2222
p.P123A	DO23627	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.6392
p.E120K	DO222402	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.25
p.P137S	DO37406	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0556
p.P130S	DO41644	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.25
p.T125N	DO41235	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7055
p.L117V	DO43891	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1667
p.A116V	DO41139	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1389
p.T125A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7139

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons