DegronMD

Uniprot ID: Q9UIB8

Source protein: SLAM family member 5

Source gene: CD84

Class: DEG_SPOP_SBC_1

Location: 336:340

E3 ligase: SPOP

DEGRON score: 0.9897

ASA_SCORE: 69.48

COIL: 0.8696

CONS_SCORE: 0.2612

DSS_SCORE: 0.6766

HELIX: 0.0332

FCONS_SCORE: 0.9619

RIG_SCORE: 0.6463

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I337T	DO222651	BTCA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7078
p.T338N	TCGA-D1-A17Q	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.7055
p.E336K	DO51639	CESC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7022
p.V338L	DO233697	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.6765
p.P335H	TCGA-AX-A06F	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.3056
p.P335H	TCGA-D1-A17Q	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.3056
p.Y335C	DO46763	PAEN	ICGC	PGTSS	DEG_SPOP_SBC_1	0.3056
p.E342K	TCGA-VS-A958	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.S334R	DO229041	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.T332N	DO41903	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.K327N	TCGA-D7-6818	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1944
p.Q331H	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.Q331H	ACH-001642	Lymphoma	CCLE	PGTSS	DEG_SPOP_SBC_1	0.1944
p.Q331H	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.P329T	DO228976	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.P329T	DO229041	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.P329H	DO41752	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.P329H	DO41903	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 18 of 18 entries

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Drug responses associated with CD84 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SPOP_SBC_1	626:630	PGTSS	SPOP	0.9994	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	870:874	PGTSS	SPOP	0.9993	More...
Q53H80	Akirin-2	DEG_SPOP_SBC_1	126:130	PGTSS	SPOP	0.9884	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1281:1285	PGTSS	SPOP	0.8916	More...
P29400	Collagen alpha-5	DEG_SPOP_SBC_1	1453:1457	PGTSS	SPOP	0.8142	More...
P09871	Complement C1s subcomponent	DEG_SPOP_SBC_1	551:555	PGTSS	SPOP	0.8928	More...
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SPOP_SBC_1	226:230	PGTSS	SPOP	0.824	More...
Q96IM9	DPY30 domain-containing protein 2	DEG_SPOP_SBC_1	123:127	PGTSS	SPOP	0.9785	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	683:687	PGTSS	SPOP	0.9947	More...
Q96PY5	Formin-like protein 2	DEG_SPOP_SBC_1	598:602	PGTSS	SPOP	0.9832	More...
Q6IPT2	Golgi associated RAB2 interactor protein 5A	DEG_SPOP_SBC_1	15:19	PGTSS	SPOP	0.9651	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	296:300	PGTSS	SPOP	0.9951	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	963:967	PGTSS	SPOP	0.9939	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	599:603	PGTSS	SPOP	0.5271	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	418:422	PGTSS	SPOP	0.9951	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	662:666	PGTSS	SPOP	0.9973	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7738:7742	PGTSS	SPOP	0.9963	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8317:8321	PGTSS	SPOP	0.9624	More...
Q96RE7	Nucleus accumbens-associated protein 1	DEG_SPOP_SBC_1	264:268	PGTSS	SPOP	0.9975	More...
Q8NGY2	Olfactory receptor 6K2	DEG_SPOP_SBC_1	317:321	PGTSS	SPOP	0.8496	More...
Q96G74	OTU domain-containing protein 5	DEG_SPOP_SBC_1	493:497	PGTSS	SPOP	0.9984	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	372:376	PGTSS	SPOP	0.9983	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	467:471	PGTSS	SPOP	0.9991	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	7:11	PGTSS	SPOP	0.7536	More...
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_SPOP_SBC_1	833:837	PGTSS	SPOP	0.9931	More...

Showing 1 to 25 of 34 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTSS

Degron related mutations and impact score

Drug responses associated with CD84 mutations

All proteins holding degron of PGTSS