DegronMD - Q7L014(DDX46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E847D	TCGA-AP-A1E0	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.E847D	DO43154	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.A306T	TCGA-B5-A11E	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1111
p.A306T	DO41644	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1111
p.G309W	TCGA-D3-A3CE	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1944
p.G309W	DO37405	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1944
p.T305A	TCGA-DF-A2KU	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation blocking phosphorylation signal	0.5278
p.T305A	DO223286	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation blocking phosphorylation signal	0.5278
p.Q311E	TCGA-E7-A7DV	BLCA	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.Q311E	TCGA-MV-A51V	BLCA	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.Q311E	DO48583	BLCA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.Q311E	DO474	BLCA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.E847K	TCGA-E7-A7DV	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.E847K	TCGA-EK-A2RA	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.E847K	DO48583	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.E847K	DO51601	CESC	ICGC	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.E319K	TCGA-EE-A2GB	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.591
p.E319K	DO222683	MELA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.591
p.E319K	DO37417	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.591
p.K325T	TCGA-FI-A2D5	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation blocking ubiquitination signal	0.6944
p.K325T	DO41331	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation blocking ubiquitination signal	0.6944
p.H323Y	TCGA-GF-A6C9	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.3056
p.H323Y	DO51254	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.3056
p.R826T	DO1094	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1389
p.Q314H	DO229035	LICA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.647
p.R332S	DO229038	LICA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.0556
p.I326M	DO23376	LINC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.2222
p.E327K	DO222572	MELA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1944
p.P839T	DO229240	THCA	ICGC	PGTSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.2778
p.R315Q	SIDM00193	Colorectal Carcinoma	GDSC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.7329
p.R315Q	ACH-000991	Colon/Colorectal Cancer	CCLE	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.7329
p.R315Q	SNU-81	large intestine	COSMIC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.7329
p.L317P	SIDM00469	Pancreatic Carcinoma	GDSC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6471
p.L317P	ACH-000320	Pancreatic Cancer	CCLE	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6471
p.L317P	PSN1	pancreas	COSMIC	QRKLLEPVD	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6471

Kaplan plot for DDX46 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX46

UniProt ID: Q7L014

Entrez ID: 9879

Protein name: Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDX46 in