DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGTSS
Uniprot ID:
Q7L014
Source protein:
Probable ATP-dependent RNA helicase DDX46
Source gene:
DDX46
Class:
DEG_SPOP_SBC_1
Location:
833:837
E3 ligase:
SPOP
DEGRON score:
0.9931
ASA_SCORE:
79.42
COIL:
0.9122
CONS_SCORE:
0.2157
DSS_SCORE:
0.5501
HELIX:
0.0432
FCONS_SCORE:
0.9181
RIG_SCORE:
0.6069
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E847D
TCGA-AP-A1E0
UCEC
TCGA
PGTSS
DEG_SPOP_SBC_1
0.0556
p.E847D
DO43154
UCEC
ICGC
PGTSS
DEG_SPOP_SBC_1
0.0556
p.E847K
TCGA-E7-A7DV
BLCA
TCGA
PGTSS
DEG_SPOP_SBC_1
0.0556
p.E847K
TCGA-EK-A2RA
CESC
TCGA
PGTSS
DEG_SPOP_SBC_1
0.0556
p.E847K
DO48583
BLCA
ICGC
PGTSS
DEG_SPOP_SBC_1
0.0556
p.E847K
DO51601
CESC
ICGC
PGTSS
DEG_SPOP_SBC_1
0.0556
p.R826T
DO1094
BRCA
ICGC
PGTSS
DEG_SPOP_SBC_1
0.1389
p.P839T
DO229240
THCA
ICGC
PGTSS
DEG_SPOP_SBC_1
0.2778
Drug responses associated with DDX46 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95071
E3 ubiquitin-protein ligase UBR5
DEG_SPOP_SBC_1
683:687
PGTSS
SPOP
0.9947
More...
P09871
Complement C1s subcomponent
DEG_SPOP_SBC_1
551:555
PGTSS
SPOP
0.8928
More...
P25054
Adenomatous polyposis coli protein
DEG_SPOP_SBC_1
870:874
PGTSS
SPOP
0.9993
More...
P29400
Collagen alpha-5
DEG_SPOP_SBC_1
1453:1457
PGTSS
SPOP
0.8142
More...
P78363
Retinal-specific phospholipid-transporting ATPase ABCA4
DEG_SPOP_SBC_1
1948:1952
PGTSS
SPOP
0.5066
More...
Q53H80
Akirin-2
DEG_SPOP_SBC_1
126:130
PGTSS
SPOP
0.9884
More...
Q5TDH0
Protein DDI1 homolog 2
DEG_SPOP_SBC_1
102:106
PGTSS
SPOP
0.9694
More...
Q659C4
La-related protein 1B
DEG_SPOP_SBC_1
662:666
PGTSS
SPOP
0.9973
More...
Q6RI45
Bromodomain and WD repeat-containing protein 3
DEG_SPOP_SBC_1
1281:1285
PGTSS
SPOP
0.8916
More...
Q7L014
Probable ATP-dependent RNA helicase DDX46
DEG_SPOP_SBC_1
833:837
PGTSS
SPOP
0.9931
More...
Q8IWN7
Retinitis pigmentosa 1-like 1 protein
DEG_SPOP_SBC_1
139:143
PGTSS
SPOP
0.9971
More...
Q8IXJ9
Polycomb group protein ASXL1
DEG_SPOP_SBC_1
467:471
PGTSS
SPOP
0.9991
More...
Q8NDX5
Polyhomeotic-like protein 3
DEG_SPOP_SBC_1
7:11
PGTSS
SPOP
0.7536
More...
Q8TDZ2
[F-actin]-monooxygenase MICAL1
DEG_SPOP_SBC_1
626:630
PGTSS
SPOP
0.9994
More...
Q8WTU0
Protein DDI1 homolog 1
DEG_SPOP_SBC_1
102:106
PGTSS
SPOP
0.9889
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7738:7742
PGTSS
SPOP
0.9963
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8317:8321
PGTSS
SPOP
0.9624
More...
Q96G74
OTU domain-containing protein 5
DEG_SPOP_SBC_1
493:497
PGTSS
SPOP
0.9984
More...
Q96L73
Histone-lysine N-methyltransferase, H3 lysine-36 specific
DEG_SPOP_SBC_1
296:300
PGTSS
SPOP
0.9951
More...
Q96PY5
Formin-like protein 2
DEG_SPOP_SBC_1
598:602
PGTSS
SPOP
0.9832
More...
Q96RE7
Nucleus accumbens-associated protein 1
DEG_SPOP_SBC_1
264:268
PGTSS
SPOP
0.9975
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_SPOP_SBC_1
864:868
PGTSS
SPOP
0.9926
More...
Q9HB58
Sp110 nuclear body protein
DEG_SPOP_SBC_1
159:163
PGTSS
SPOP
0.9408
More...
Q9NYI0
PH and SEC7 domain-containing protein 3
DEG_SPOP_SBC_1
372:376
PGTSS
SPOP
0.9983
More...
Q9P202
Whirlin
DEG_SPOP_SBC_1
637:641
PGTSS
SPOP
0.9454
More...
Q9P2N6
KAT8 regulatory NSL complex subunit 3
DEG_SPOP_SBC_1
599:603
PGTSS
SPOP
0.5271
More...
Q9UIB8
SLAM family member 5
DEG_SPOP_SBC_1
336:340
PGTSS
SPOP
0.9897
More...
Q9Y4H2
Insulin receptor substrate 2
DEG_SPOP_SBC_1
963:967
PGTSS
SPOP
0.9939
More...
Q96AC6
Kinesin-like protein KIFC2
DEG_SPOP_SBC_1
418:422
PGTSS
SPOP
0.9951
More...
Q96SC8
Doublesex- and mab-3-related transcription factor A2
DEG_SPOP_SBC_1
226:230
PGTSS
SPOP
0.824
More...
Q8NGY2
Olfactory receptor 6K2
DEG_SPOP_SBC_1
317:321
PGTSS
SPOP
0.8496
More...
Q96IM9
DPY30 domain-containing protein 2
DEG_SPOP_SBC_1
123:127
PGTSS
SPOP
0.9785
More...
Q9NW07
Zinc finger protein 358
DEG_SPOP_SBC_1
454:458
PGTSS
SPOP
0.9051
More...
Q6IPT2
Golgi associated RAB2 interactor protein 5A
DEG_SPOP_SBC_1
15:19
PGTSS
SPOP
0.9651
More...