DegronMD - Q8WTU0(DDI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G98C	TCGA-09-2044	OV	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.G98C	DO28923	OV	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.R108S	TCGA-50-5930	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108S	DO25189	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.A100E	TCGA-77-7465	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.A100E	DO27699	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108G	TCGA-78-7148	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108G	DO26112	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.G98S	TCGA-78-7158	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.G98S	DO24729	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.P102H	TCGA-95-7043	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7694
p.P102H	DO24739	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7694
p.R108C	TCGA-AA-A01P	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108C	DO8642	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.H111L	TCGA-AZ-6598	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1944
p.H111L	DO10276	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1944
p.S106N	TCGA-DU-6392	LGG	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7069
p.S106N	DO22237	LGG	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7069
p.R108H	TCGA-DU-7012	LGG	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108H	TCGA-HC-8265	PRAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108H	DO22187	LGG	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108H	DO36289	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.G113R	TCGA-EE-A3AA	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1389
p.G113R	DO222632	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1389
p.G113R	DO37571	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1389
p.F96V	DO50450	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1667
p.R93H	DO231652	LINC	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R93H	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R93H	ACH-000855	Esophageal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R93H	KYSE-150	oesophagus	COSMIC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R108L	DO23544	LIRI	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.G98D	DO232761	PBCA	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.V94A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1111
p.V94A	ACH-000920	Leukemia	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.1111
p.G103A	SIDM00373	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00588	Oral Cavity Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01197	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00553	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00492	Glioblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00568	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00360	Other Solid Cancers	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00817	Kidney Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00024	Non-Cancerous	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00365	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00970	Bladder Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00324	Neuroblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00316	Glioblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01695	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01551	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01609	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01511	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01460	Glioma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01394	Kidney Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01575	Plasma Cell Myeloma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01782	Oral Cavity Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM00500	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01774	Pancreatic Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.G103A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6429
p.S107Y	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation blocking phosphorylation signal	0.75
p.S107Y	ACH-000667	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation blocking phosphorylation signal	0.75
p.S107Y	HCC-44	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation blocking phosphorylation signal	0.75
p.S105F	SIDM00013	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7982
p.S105F	ACH-002387	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7982
p.S106I	ACH-000982	Colon/Colorectal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.7341

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDI1

UniProt ID: Q8WTU0

Entrez ID: 414301

Protein name: Protein DDI1 homolog 1 (EC 3.4.23.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDI1 in