DegronMD

Uniprot ID: Q8WTU0

Source protein: Protein DDI1 homolog 1

Source gene: DDI1

Class: DEG_SPOP_SBC_1

Location: 102:106

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 67.24

COIL: 0.8966

CONS_SCORE: 0.1804

DSS_SCORE: 0.7918

HELIX: 0.0644

FCONS_SCORE: 1.0532

RIG_SCORE: 0.5419

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G98C	TCGA-09-2044	OV	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2222
p.G98C	DO28923	OV	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.R108S	TCGA-50-5930	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108S	DO25189	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.A100E	TCGA-77-7465	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.A100E	DO27699	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108G	TCGA-78-7148	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108G	DO26112	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.G98S	TCGA-78-7158	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2222
p.G98S	DO24729	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.P102H	TCGA-95-7043	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.7694
p.P102H	DO24739	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7694
p.R108C	TCGA-AA-A01P	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108C	DO8642	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.H111L	TCGA-AZ-6598	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1944
p.H111L	DO10276	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.S106N	TCGA-DU-6392	LGG	TCGA	PGTSS	DEG_SPOP_SBC_1	0.7069
p.S106N	DO22237	LGG	ICGC	PGTSS	DEG_SPOP_SBC_1	0.7069
p.R108H	TCGA-DU-7012	LGG	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108H	TCGA-HC-8265	PRAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108H	DO22187	LGG	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R108H	DO36289	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.G113R	TCGA-EE-A3AA	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1389
p.G113R	DO222632	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.G113R	DO37571	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.F96V	DO50450	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1667
p.R93H	DO231652	LINC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R93H	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R93H	ACH-000855	Esophageal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R93H	KYSE-150	oesophagus	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R108L	DO23544	LIRI	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.G98D	DO232761	PBCA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.V94A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.V94A	ACH-000920	Leukemia	CCLE	PGTSS	DEG_SPOP_SBC_1	0.1111
p.G103A	SIDM00373	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00588	Oral Cavity Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01197	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00553	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00492	Glioblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00568	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00360	Other Solid Cancers	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00817	Kidney Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00024	Non-Cancerous	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00365	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00970	Bladder Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00324	Neuroblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00316	Glioblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01695	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01551	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01609	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01511	Gastric Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01460	Glioma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01394	Kidney Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01575	Plasma Cell Myeloma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01782	Oral Cavity Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM00500	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01774	Pancreatic Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.G103A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6429
p.S107Y	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.75
p.S107Y	ACH-000667	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.75
p.S107Y	HCC-44	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.75
p.S105F	SIDM00013	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.7982
p.S105F	ACH-002387	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.7982
p.S106I	ACH-000982	Colon/Colorectal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	683:687	PGTSS	SPOP	0.9947	More...
P09871	Complement C1s subcomponent	DEG_SPOP_SBC_1	551:555	PGTSS	SPOP	0.8928	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	870:874	PGTSS	SPOP	0.9993	More...
P29400	Collagen alpha-5	DEG_SPOP_SBC_1	1453:1457	PGTSS	SPOP	0.8142	More...
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_SPOP_SBC_1	1948:1952	PGTSS	SPOP	0.5066	More...
Q53H80	Akirin-2	DEG_SPOP_SBC_1	126:130	PGTSS	SPOP	0.9884	More...
Q5TDH0	Protein DDI1 homolog 2	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9694	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	662:666	PGTSS	SPOP	0.9973	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1281:1285	PGTSS	SPOP	0.8916	More...
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_SPOP_SBC_1	833:837	PGTSS	SPOP	0.9931	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	139:143	PGTSS	SPOP	0.9971	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	467:471	PGTSS	SPOP	0.9991	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	7:11	PGTSS	SPOP	0.7536	More...
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SPOP_SBC_1	626:630	PGTSS	SPOP	0.9994	More...
Q8WTU0	Protein DDI1 homolog 1	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9889	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7738:7742	PGTSS	SPOP	0.9963	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8317:8321	PGTSS	SPOP	0.9624	More...
Q96G74	OTU domain-containing protein 5	DEG_SPOP_SBC_1	493:497	PGTSS	SPOP	0.9984	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	296:300	PGTSS	SPOP	0.9951	More...
Q96PY5	Formin-like protein 2	DEG_SPOP_SBC_1	598:602	PGTSS	SPOP	0.9832	More...
Q96RE7	Nucleus accumbens-associated protein 1	DEG_SPOP_SBC_1	264:268	PGTSS	SPOP	0.9975	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	864:868	PGTSS	SPOP	0.9926	More...
Q9HB58	Sp110 nuclear body protein	DEG_SPOP_SBC_1	159:163	PGTSS	SPOP	0.9408	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	372:376	PGTSS	SPOP	0.9983	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	637:641	PGTSS	SPOP	0.9454	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	599:603	PGTSS	SPOP	0.5271	More...
Q9UIB8	SLAM family member 5	DEG_SPOP_SBC_1	336:340	PGTSS	SPOP	0.9897	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	963:967	PGTSS	SPOP	0.9939	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	418:422	PGTSS	SPOP	0.9951	More...
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SPOP_SBC_1	226:230	PGTSS	SPOP	0.824	More...
Q8NGY2	Olfactory receptor 6K2	DEG_SPOP_SBC_1	317:321	PGTSS	SPOP	0.8496	More...
Q96IM9	DPY30 domain-containing protein 2	DEG_SPOP_SBC_1	123:127	PGTSS	SPOP	0.9785	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	454:458	PGTSS	SPOP	0.9051	More...
Q6IPT2	Golgi associated RAB2 interactor protein 5A	DEG_SPOP_SBC_1	15:19	PGTSS	SPOP	0.9651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTSS

Degron related mutations and impact score

Drug responses associated with DDI1 mutations

All proteins holding degron of PGTSS