DegronMD - Q5TDH0(DDI2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P102S	TCGA-AA-A022	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6752
p.P102S	DO10647	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation altering degron motif	0.6752
p.R108Q	TCGA-AZ-4615	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108Q	DO7977	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108Q	SIDM00499	Prostate Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108Q	ACH-000956	Prostate Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R108Q	22RV1	prostate	COSMIC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.K77M	TCGA-D3-A3ML	SKCM	TCGA	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.8062
p.K77M	DO47413	SKCM	ICGC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.8062
p.A100D	TCGA-HE-7128	KIRP	TCGA	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.A100D	DO20796	KIRP	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2778
p.R75Q	DO222600	COCA	ICGC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.3056
p.Q116H	DO229038	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0556
p.R110S	DO50710	ORCA	ICGC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.N79S	SIDM00304	Ovarian Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.7069
p.N79S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.7069
p.N79S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.7069
p.N79S	SIDM00160	Biliary Tract Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.7069
p.N79S	SIDM00162	Biliary Tract Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.7069
p.R110C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.R110C	ACH-000945	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.R110C	NCI-H650	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222
p.R93Q	SIDM01322	Oral Cavity Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R93Q	ACH-000735	Head and Neck Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.0833
p.R110H	SIDM01617	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	102:106	Mutation rewiring degron network	0.2222

Kaplan plot for DDI2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDI2

UniProt ID: Q5TDH0

Entrez ID: 84301

Protein name: Protein DDI1 homolog 2 (EC 3.4.23.-)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DDI2 in