DegronMD

Uniprot ID: Q5TDH0

Source protein: Protein DDI1 homolog 2

Source gene: DDI2

Class: DEG_APCC_KENBOX_2

Location: 76:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8906

ASA_SCORE: 94.42

COIL: 0.74

CONS_SCORE: 0.2302

DSS_SCORE: 0.5318

HELIX: 0.0226

FCONS_SCORE: 0.7404

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K77M	TCGA-D3-A3ML	SKCM	TCGA	QKENA	DEG_APCC_KENBOX_2	0.8062
p.K77M	DO47413	SKCM	ICGC	QKENA	DEG_APCC_KENBOX_2	0.8062
p.R75Q	DO222600	COCA	ICGC	QKENA	DEG_APCC_KENBOX_2	0.3056
p.N79S	SIDM00304	Ovarian Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	0.7069
p.N79S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	0.7069
p.N79S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENA	DEG_APCC_KENBOX_2	0.7069
p.N79S	SIDM00160	Biliary Tract Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	0.7069
p.N79S	SIDM00162	Biliary Tract Carcinoma	GDSC	QKENA	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TDH0	Protein DDI1 homolog 2	DEG_APCC_KENBOX_2	76:80	QKENA	APC,CDC20,FZR1	0.8906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons