DegronMD - P78363(ABCA4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1456C	TCGA-09-2044	OV	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2222
p.G1456C	DO28923	OV	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2222
p.E1278K	TCGA-21-1079	LUSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1278K	TCGA-CR-6481	HNSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1278K	TCGA-ER-A194	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1278K	DO14990	HNSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1278K	DO26846	LUSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1278K	DO47646	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1389
p.E1270D	TCGA-46-3769	LUSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.5647
p.E1270D	DO26590	LUSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.5647
p.T1497S	TCGA-61-2012	OV	TCGA	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6005
p.T1497S	DO32536	OV	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6005
p.G1949V	TCGA-64-1679	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation altering degron motif	0.6421
p.G1949V	DO26200	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation altering degron motif	0.6421
p.G2059C	TCGA-75-6214	LUAD	TCGA	LTVYAD	LIG_APCC_ABBA_1	2060:2065	Mutation rewiring degron network	0.3056
p.G2059C	TCGA-DA-A1I7	SKCM	TCGA	LTVYAD	LIG_APCC_ABBA_1	2060:2065	Mutation rewiring degron network	0.3056
p.T1277M	TCGA-AG-3591	READ	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1667
p.T1277M	DO222884	COCA	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1667
p.T1277M	DO37316	READ	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1667
p.L1259I	TCGA-AG-A002	READ	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1944
p.L1259I	SIDM00491	Thyroid Gland Carcinoma	GDSC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1944
p.L1259I	ACH-001443	Thyroid Cancer	CCLE	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1944
p.L1259I	ASH-3	thyroid	COSMIC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1944
p.N2075D	TCGA-AJ-A3OK	UCEC	TCGA	LTVYAD	LIG_APCC_ABBA_1	2060:2065	Mutation rewiring degron network	0.0556
p.P1451S	TCGA-AP-A056	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.0833
p.P1451S	DO43971	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.0833
p.D1956Y	TCGA-C5-A2LX	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation rewiring degron network	0.2222
p.Q1475H	TCGA-D3-A1Q1	SKCM	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1111
p.Q1475H	DO37445	SKCM	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1111
p.E1270K	TCGA-D3-A2JF	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.591
p.E1270K	TCGA-ER-A19G	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.591
p.E1270K	DO47284	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.591
p.E1270K	DO38153	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.591
p.Y1453N	TCGA-DD-A3A9	LIHC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1389
p.Y1453N	DO44888	LIHC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1389
p.P1464H	TCGA-DF-A2KN	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation altering degron motif	0.7694
p.P1464H	DO223282	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation altering degron motif	0.7694
p.D2065N	TCGA-DU-6392	LGG	TCGA	LTVYAD	LIG_APCC_ABBA_1	2060:2065	Mutation altering degron motif	0.6932
p.P1268L	TCGA-EB-A41A	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.7582
p.P1268L	DO220851	MELA	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.7582
p.P1268L	DO37429	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation altering degron motif	0.7582
p.G1961R	TCGA-EE-A2MI	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation rewiring degron network	0.0833
p.G1961R	DO37531	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation rewiring degron network	0.0833
p.N1469D	TCGA-EO-A22U	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2778
p.N1469D	DO43755	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2778
p.D1279N	TCGA-GF-A6C9	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1111
p.D1279N	DO51254	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	1264:1271	Mutation rewiring degron network	0.1111
p.W1461L	TCGA-HE-7129	KIRP	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation altering degron motif	0.5904
p.W1461L	DO20786	KIRP	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation altering degron motif	0.5904
p.G1505S	DO720	BLCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1944
p.E1504K	DO48270	ESCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2222
p.V1482I	DO228918	LICA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.0556
p.N1483K	DO228948	LICA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.0833
p.S1952R	DO229031	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation altering degron motif	0.7427
p.P1468S	DO23511	LIRI	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.3056
p.P1451L	DO52680	MALY	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.0833
p.P1486S	DO220857	MELA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.G1507R	DO229245	THCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1389
p.G1507R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1389
p.G1507R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1389
p.P1454S	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1667
p.P1454S	ACH-000509	Lymphoma	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1667
p.P1454S	ACH-002240	Lymphoma	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1667
p.P1454S	H9	haematopoietic and lymphoid tissue	COSMIC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.1667
p.N1469S	SIDM00009	Acute Myeloid Leukemia	GDSC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2778
p.N1469S	ACH-002390	Leukemia	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2778
p.N1469S	MC-1010	haematopoietic and lymphoid tissue	COSMIC	PWKTPSVS	DEG_SCF_FBW7_1	1460:1467	Mutation rewiring degron network	0.2778
p.P1486T	SIDM01084	Osteosarcoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.P1486T	ACH-000410	Bone Cancer	CCLE	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.P1486T	Saos-2	bone	COSMIC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.R1489S	SIDM00641	Burkitt's Lymphoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.E1501D	SIDM01409	Bladder Carcinoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.3056
p.R1957M	ACH-001061	Colon/Colorectal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	1948:1952	Mutation rewiring degron network	0.1944
p.P1510L	ACH-001119	Lymphoma	CCLE	TREKLTMLP	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.0556

Kaplan plot for ABCA4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCA4

UniProt ID: P78363

Entrez ID: 24

Protein name: Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ABCA4 in