DegronMD

Uniprot ID: P78363

Source protein: Retinal-specific phospholipid-transporting ATPase ABCA4

Source gene: ABCA4

Class: DEG_APCC_DBOX_1

Location: 1492:1500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.716

ASA_SCORE: 62.7667

COIL: 0.651

CONS_SCORE: 0.1839

DSS_SCORE: 0.4375

HELIX: 0.0484

FCONS_SCORE: 0.8534

RIG_SCORE: 0.7338

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1497S	TCGA-61-2012	OV	TCGA	TREKLTMLP	DEG_APCC_DBOX_1	0.6005
p.T1497S	DO32536	OV	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.6005
p.G1505S	DO720	BLCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.1944
p.E1504K	DO48270	ESCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.2222
p.V1482I	DO228918	LICA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.0556
p.N1483K	DO228948	LICA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.0833
p.P1486S	DO220857	MELA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.1667
p.G1507R	DO229245	THCA	ICGC	TREKLTMLP	DEG_APCC_DBOX_1	0.1389
p.G1507R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	0.1389
p.G1507R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TREKLTMLP	DEG_APCC_DBOX_1	0.1389
p.P1486T	SIDM01084	Osteosarcoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	0.1667
p.P1486T	ACH-000410	Bone Cancer	CCLE	TREKLTMLP	DEG_APCC_DBOX_1	0.1667
p.P1486T	Saos-2	bone	COSMIC	TREKLTMLP	DEG_APCC_DBOX_1	0.1667
p.R1489S	SIDM00641	Burkitt's Lymphoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	0.25
p.E1501D	SIDM01409	Bladder Carcinoma	GDSC	TREKLTMLP	DEG_APCC_DBOX_1	0.3056
p.P1510L	ACH-001119	Lymphoma	CCLE	TREKLTMLP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_APCC_DBOX_1	1492:1500	TREKLTMLP	APC,CDC20,FZR1	0.716	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons