DegronMD

Uniprot ID: P78363

Source protein: Retinal-specific phospholipid-transporting ATPase ABCA4

Source gene: ABCA4

Class: DEG_SCF_FBW7_2

Location: 1264:1271

E3 ligase: FBXW7

DEGRON score: 0.7196

ASA_SCORE: 37.25

COIL: 0.3585

CONS_SCORE: 0.625

DSS_SCORE: 0.2148

HELIX: 0.3806

FCONS_SCORE: 1.419

RIG_SCORE: 0.7965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1278K	TCGA-21-1079	LUSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1278K	TCGA-CR-6481	HNSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1278K	TCGA-ER-A194	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1278K	DO14990	HNSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1278K	DO26846	LUSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1278K	DO47646	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1389
p.E1270D	TCGA-46-3769	LUSC	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.5647
p.E1270D	DO26590	LUSC	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.5647
p.T1277M	TCGA-AG-3591	READ	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1667
p.T1277M	DO222884	COCA	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1667
p.T1277M	DO37316	READ	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1667
p.L1259I	TCGA-AG-A002	READ	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1944
p.L1259I	SIDM00491	Thyroid Gland Carcinoma	GDSC	ISDTPLEE	DEG_SCF_FBW7_2	0.1944
p.L1259I	ACH-001443	Thyroid Cancer	CCLE	ISDTPLEE	DEG_SCF_FBW7_2	0.1944
p.L1259I	ASH-3	thyroid	COSMIC	ISDTPLEE	DEG_SCF_FBW7_2	0.1944
p.E1270K	TCGA-D3-A2JF	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.591
p.E1270K	TCGA-ER-A19G	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.591
p.E1270K	DO47284	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.591
p.E1270K	DO38153	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.591
p.P1268L	TCGA-EB-A41A	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.7582
p.P1268L	DO220851	MELA	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.7582
p.P1268L	DO37429	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.7582
p.D1279N	TCGA-GF-A6C9	SKCM	TCGA	ISDTPLEE	DEG_SCF_FBW7_2	0.1111
p.D1279N	DO51254	SKCM	ICGC	ISDTPLEE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_SCF_FBW7_2	1264:1271	ISDTPLEE	FBXW7	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons