DegronMD

Uniprot ID: P78363

Source protein: Retinal-specific phospholipid-transporting ATPase ABCA4

Source gene: ABCA4

Class: DEG_SCF_FBW7_1

Location: 1460:1467

E3 ligase: FBXW7

DEGRON score: 0.5192

ASA_SCORE: 69.6

COIL: 0.924

CONS_SCORE: 0.1931

DSS_SCORE: 0.4735

HELIX: 0.033

FCONS_SCORE: 1.0245

RIG_SCORE: 0.7395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1456C	TCGA-09-2044	OV	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.2222
p.G1456C	DO28923	OV	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.2222
p.P1451S	TCGA-AP-A056	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.0833
p.P1451S	DO43971	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.0833
p.Q1475H	TCGA-D3-A1Q1	SKCM	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.1111
p.Q1475H	DO37445	SKCM	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.1111
p.Y1453N	TCGA-DD-A3A9	LIHC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.1389
p.Y1453N	DO44888	LIHC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.1389
p.P1464H	TCGA-DF-A2KN	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.7694
p.P1464H	DO223282	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.7694
p.N1469D	TCGA-EO-A22U	UCEC	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.2778
p.N1469D	DO43755	UCEC	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.2778
p.W1461L	TCGA-HE-7129	KIRP	TCGA	PWKTPSVS	DEG_SCF_FBW7_1	0.5904
p.W1461L	DO20786	KIRP	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.5904
p.P1468S	DO23511	LIRI	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.3056
p.P1451L	DO52680	MALY	ICGC	PWKTPSVS	DEG_SCF_FBW7_1	0.0833
p.P1454S	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PWKTPSVS	DEG_SCF_FBW7_1	0.1667
p.P1454S	ACH-000509	Lymphoma	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	0.1667
p.P1454S	ACH-002240	Lymphoma	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	0.1667
p.P1454S	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PWKTPSVS	DEG_SCF_FBW7_1	0.1667
p.N1469S	SIDM00009	Acute Myeloid Leukemia	GDSC	PWKTPSVS	DEG_SCF_FBW7_1	0.2778
p.N1469S	ACH-002390	Leukemia	CCLE	PWKTPSVS	DEG_SCF_FBW7_1	0.2778
p.N1469S	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	PWKTPSVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_SCF_FBW7_1	1460:1467	PWKTPSVS	FBXW7	0.5192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons