DegronMD

Uniprot ID: P78363

Source protein: Retinal-specific phospholipid-transporting ATPase ABCA4

Source gene: ABCA4

Class: LIG_APCC_ABBA_1

Location: 2060:2065

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5181

ASA_SCORE: 53.6833

COIL: 0.458

CONS_SCORE: 0.4692

DSS_SCORE: 0.0269

HELIX: 0.4568

FCONS_SCORE: 0.8188

RIG_SCORE: 0.9368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2059C	TCGA-75-6214	LUAD	TCGA	LTVYAD	LIG_APCC_ABBA_1	0.3056
p.G2059C	TCGA-DA-A1I7	SKCM	TCGA	LTVYAD	LIG_APCC_ABBA_1	0.3056
p.N2075D	TCGA-AJ-A3OK	UCEC	TCGA	LTVYAD	LIG_APCC_ABBA_1	0.0556
p.D2065N	TCGA-DU-6392	LGG	TCGA	LTVYAD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	LIG_APCC_ABBA_1	2060:2065	LTVYAD	APC,CDC20,FZR1	0.5181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons