DegronMD - Q96SC8(DMRTA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K215Q	TCGA-49-4487	LUAD	TCGA	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation substituting flanking lysine	0.2222
p.K215Q	DO24780	LUAD	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation substituting flanking lysine	0.2222
p.R329L	TCGA-EE-A2ME	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.1111
p.R329L	DO38011	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.1111
p.R328W	TCGA-ER-A19B	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.1389
p.R328W	DO47491	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.1389
p.P325T	TCGA-FS-A1ZR	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.2222
p.P325T	DO37651	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.2222
p.R312W	TCGA-HF-A5NB	STAD	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.3056
p.R312W	DO50127	STAD	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.3056
p.R314Q	TCGA-VQ-A8P2	STAD	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation altering degron motif	0.7329
p.R314Q	DO51761	STAD	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation altering degron motif	0.7329
p.G238D	DO234183	ESAD	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.0833
p.G238D	DO234183	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.A14V	DO233624	GACA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.25
p.G304R	DO233899	GACA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.0833
p.G238S	DO220891	MELA	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.0833
p.G238S	DO220891	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.R4H	DO220911	MELA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.8244
p.G307R	DO222702	MELA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation rewiring degron network	0.1667
p.L317Q	DO229216	THCA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation altering degron motif	0.7765
p.G12V	DO229211	THCA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.T315M	SIDM01956	Colorectal Carcinoma	GDSC	QRTPLDILT	DEG_APCC_DBOX_1	313:321	Mutation altering degron motif	0.6312
p.G225E	SIDM00496	Thyroid Gland Carcinoma	GDSC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.7199
p.G225E	ACH-001350	Thyroid Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.7199
p.G225E	HTC-C3	thyroid	COSMIC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.7199
p.A222S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.3056
p.A222S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.A222S	ACH-000757	Lung Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.3056
p.A222S	ACH-000757	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.A222S	A427	lung	COSMIC	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.3056
p.A222S	A427	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.V10L	ACH-000776	Brain Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.5654
p.E2D	ACH-000777	Esophageal Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.A17V	ACH-000859	Breast Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.L7P	ACH-000982	Colon/Colorectal Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7582
p.E232G	ACH-001610	Brain Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.25
p.E232G	ACH-001610	Brain Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778

Kaplan plot for DMRTA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMRTA2

UniProt ID: Q96SC8

Entrez ID: 63950

Protein name: Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMRTA2 in