DegronMD

Uniprot ID: Q96SC8

Source protein: Doublesex- and mab-3-related transcription factor A2

Source gene: DMRTA2

Class: DEG_APCC_DBOX_1

Location: 313:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8453

ASA_SCORE: 68.4444

COIL: 0.5478

CONS_SCORE: 0.6004

DSS_SCORE: 0.5498

HELIX: 0.3211

FCONS_SCORE: 1.1539

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R329L	TCGA-EE-A2ME	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	0.1111
p.R329L	DO38011	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.1111
p.R328W	TCGA-ER-A19B	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	0.1389
p.R328W	DO47491	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.1389
p.P325T	TCGA-FS-A1ZR	SKCM	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	0.2222
p.P325T	DO37651	SKCM	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.2222
p.R312W	TCGA-HF-A5NB	STAD	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	0.3056
p.R312W	DO50127	STAD	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.3056
p.R314Q	TCGA-VQ-A8P2	STAD	TCGA	QRTPLDILT	DEG_APCC_DBOX_1	0.7329
p.R314Q	DO51761	STAD	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.7329
p.G304R	DO233899	GACA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.0833
p.G307R	DO222702	MELA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.1667
p.L317Q	DO229216	THCA	ICGC	QRTPLDILT	DEG_APCC_DBOX_1	0.7765
p.T315M	SIDM01956	Colorectal Carcinoma	GDSC	QRTPLDILT	DEG_APCC_DBOX_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_APCC_DBOX_1	313:321	QRTPLDILT	APC,CDC20,FZR1	0.8453	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons