DegronMD

Uniprot ID: Q96SC8

Source protein: Doublesex- and mab-3-related transcription factor A2

Source gene: DMRTA2

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9519

ASA_SCORE: 95.0333

COIL: 0.9222

CONS_SCORE: 0.3423

DSS_SCORE: 0.6081

HELIX: 0.0464

FCONS_SCORE: 1.0589

RIG_SCORE: 0.7131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A14V	DO233624	GACA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	0.25
p.R4H	DO220911	MELA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	0.8244
p.G12V	DO229211	THCA	ICGC	LRSELPSVP	DEG_APCC_DBOX_1	0.3056
p.V10L	ACH-000776	Brain Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	0.5654
p.E2D	ACH-000777	Esophageal Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	0.3056
p.A17V	ACH-000859	Breast Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	0.1667
p.L7P	ACH-000982	Colon/Colorectal Cancer	CCLE	LRSELPSVP	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_APCC_DBOX_1	3:11	LRSELPSVP	APC,CDC20,FZR1	0.9519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons