DegronMD

Uniprot ID: Q96SC8

Source protein: Doublesex- and mab-3-related transcription factor A2

Source gene: DMRTA2

Class: DEG_SCF_TRCP1_1

Location: 223:229

E3 ligase: BTRC

DEGRON score: 0.8131

ASA_SCORE: 60.6571

COIL: 0.9024

CONS_SCORE: 0.436

DSS_SCORE: 0.8243

HELIX: 0.0324

FCONS_SCORE: 0.9533

RIG_SCORE: 0.4611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K215Q	TCGA-49-4487	LUAD	TCGA	DSGPGTS	DEG_SCF_TRCP1_1	0.2222
p.K215Q	DO24780	LUAD	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	0.2222
p.G238D	DO234183	ESAD	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	0.0833
p.G238S	DO220891	MELA	ICGC	DSGPGTS	DEG_SCF_TRCP1_1	0.0833
p.G225E	SIDM00496	Thyroid Gland Carcinoma	GDSC	DSGPGTS	DEG_SCF_TRCP1_1	0.7199
p.G225E	ACH-001350	Thyroid Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	0.7199
p.G225E	HTC-C3	thyroid	COSMIC	DSGPGTS	DEG_SCF_TRCP1_1	0.7199
p.A222S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	DSGPGTS	DEG_SCF_TRCP1_1	0.3056
p.A222S	ACH-000757	Lung Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	0.3056
p.A222S	A427	lung	COSMIC	DSGPGTS	DEG_SCF_TRCP1_1	0.3056
p.E232G	ACH-001610	Brain Cancer	CCLE	DSGPGTS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SCF_TRCP1_1	223:229	DSGPGTS	BTRC	0.8131	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons