DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 78.6

COIL: 0.923

CONS_SCORE: 0.5766

DSS_SCORE: 0.7736

HELIX: 0.0504

FCONS_SCORE: 1.1095

RIG_SCORE: 0.5568

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L148F	TCGA-A5-A0G1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1944
p.L148F	DO42472	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.G140D	TCGA-AP-A059	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.6087
p.G140D	DO41361	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.6087
p.E133K	TCGA-CN-4734	HNSC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1667
p.E133K	DO233877	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1667
p.E133K	DO15446	HNSC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1667
p.E137K	TCGA-D3-A3MR	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.E137K	TCGA-FW-A3R5	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.E137K	DO47256	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.E137K	DO37406	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R152Q	TCGA-DI-A1BU	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R152Q	DO42023	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R152Q	SIDM00373	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.P151L	TCGA-ER-A193	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1111
p.P151L	DO47368	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.R130L	TCGA-L9-A7SV	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	DO49875	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	ACH-000590	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	ACH-001137	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130L	NCI-H1993	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.Q135R	TCGA-MX-A5UJ	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2222
p.Q135R	DO48547	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.R136H	DO222765	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.25
p.R136H	DO51507	PACA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.25
p.T150P	DO234303	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.T150P	DO51478	PACA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.R136C	DO234453	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.25
p.Q135K	DO228732	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2222
p.R145Q	SIDM02043	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R130W	SIDM01100	Neuroblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130W	ACH-000366	Neuroblastoma	CCLE	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130W	SK-N-DZ	autonomic_ganglia	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.D131N	SIDM00140	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.D131N	ACH-000968	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.1111
p.D131N	COLO-792	skin	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.R130Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.R130Q	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.0833
p.A138T	ACH-000123	Ovarian Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	683:687	PGTSS	SPOP	0.9947	More...
P09871	Complement C1s subcomponent	DEG_SPOP_SBC_1	551:555	PGTSS	SPOP	0.8928	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	870:874	PGTSS	SPOP	0.9993	More...
P29400	Collagen alpha-5	DEG_SPOP_SBC_1	1453:1457	PGTSS	SPOP	0.8142	More...
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_SPOP_SBC_1	1948:1952	PGTSS	SPOP	0.5066	More...
Q53H80	Akirin-2	DEG_SPOP_SBC_1	126:130	PGTSS	SPOP	0.9884	More...
Q5TDH0	Protein DDI1 homolog 2	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9694	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	662:666	PGTSS	SPOP	0.9973	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1281:1285	PGTSS	SPOP	0.8916	More...
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_SPOP_SBC_1	833:837	PGTSS	SPOP	0.9931	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	139:143	PGTSS	SPOP	0.9971	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	467:471	PGTSS	SPOP	0.9991	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	7:11	PGTSS	SPOP	0.7536	More...
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SPOP_SBC_1	626:630	PGTSS	SPOP	0.9994	More...
Q8WTU0	Protein DDI1 homolog 1	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9889	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7738:7742	PGTSS	SPOP	0.9963	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8317:8321	PGTSS	SPOP	0.9624	More...
Q96G74	OTU domain-containing protein 5	DEG_SPOP_SBC_1	493:497	PGTSS	SPOP	0.9984	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	296:300	PGTSS	SPOP	0.9951	More...
Q96PY5	Formin-like protein 2	DEG_SPOP_SBC_1	598:602	PGTSS	SPOP	0.9832	More...
Q96RE7	Nucleus accumbens-associated protein 1	DEG_SPOP_SBC_1	264:268	PGTSS	SPOP	0.9975	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	864:868	PGTSS	SPOP	0.9926	More...
Q9HB58	Sp110 nuclear body protein	DEG_SPOP_SBC_1	159:163	PGTSS	SPOP	0.9408	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	372:376	PGTSS	SPOP	0.9983	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	637:641	PGTSS	SPOP	0.9454	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	599:603	PGTSS	SPOP	0.5271	More...
Q9UIB8	SLAM family member 5	DEG_SPOP_SBC_1	336:340	PGTSS	SPOP	0.9897	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	963:967	PGTSS	SPOP	0.9939	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	418:422	PGTSS	SPOP	0.9951	More...
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SPOP_SBC_1	226:230	PGTSS	SPOP	0.824	More...
Q8NGY2	Olfactory receptor 6K2	DEG_SPOP_SBC_1	317:321	PGTSS	SPOP	0.8496	More...
Q96IM9	DPY30 domain-containing protein 2	DEG_SPOP_SBC_1	123:127	PGTSS	SPOP	0.9785	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	454:458	PGTSS	SPOP	0.9051	More...
Q6IPT2	Golgi associated RAB2 interactor protein 5A	DEG_SPOP_SBC_1	15:19	PGTSS	SPOP	0.9651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTSS

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of PGTSS