DegronMD - Q96AC6(KIFC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K756M	TCGA-34-8455	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	746:750	Mutation substituting flanking lysine	0.2778
p.K756M	DO50095	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	746:750	Mutation substituting flanking lysine	0.2778
p.R808W	TCGA-BT-A2LB	BLCA	TCGA	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0556
p.R808W	DO44098	BLCA	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0556
p.S745P	TCGA-DD-AACZ	LIHC	TCGA	APSSS	DEG_SPOP_SBC_1	746:750	Mutation rewiring degron network	0.3056
p.S745P	DO52216	LIHC	ICGC	APSSS	DEG_SPOP_SBC_1	746:750	Mutation rewiring degron network	0.3056
p.P784L	TCGA-W3-AA1V	SKCM	TCGA	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1667
p.P784L	DO51276	SKCM	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1667
p.S421F	DO223106	ESCA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.9093
p.S426N	DO228902	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2222
p.S758N	DO228965	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	746:750	Mutation rewiring degron network	0.1111
p.G408V	DO229025	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.R417M	DO229041	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.3056
p.A746T	DO231906	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	746:750	Mutation altering degron motif	0.7139
p.R808L	DO45075	LINC	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0556
p.R415W	DO220872	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.25
p.R411C	DO232761	PBCA	ICGC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1389
p.P789S	DO229084	THCA	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.3056
p.L416Q	SIDM00334	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.L416Q	ACH-000879	Endometrial/Uterine Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.L416Q	MFE-296	endometrium	COSMIC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.R792S	SIDM00789	Colorectal Carcinoma	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation altering degron motif	0.6316
p.R792S	ACH-000997	Colon/Colorectal Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation altering degron motif	0.6316
p.R792S	ACH-001061	Colon/Colorectal Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation altering degron motif	0.6316
p.L781I	SIDM00696	Non-Cancerous	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0833
p.L781I	SIDM00772	Breast Carcinoma	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0833
p.L781I	ACH-000755	Breast Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.0833
p.S426R	SIDM00221	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2222
p.R736H	ACH-000994	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	746:750	Mutation rewiring degron network	0.0556

Kaplan plot for KIFC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIFC2

UniProt ID: Q96AC6

Entrez ID: 90990

Protein name: Kinesin-like protein KIFC2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIFC2 in