DegronMD

Uniprot ID: Q96AC6

Source protein: Kinesin-like protein KIFC2

Source gene: KIFC2

Class: DEG_APCC_DBOX_1

Location: 790:798

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8356

ASA_SCORE: 111.2889

COIL: 0.748

CONS_SCORE: 0.2456

DSS_SCORE: 0.583

HELIX: 0.2271

FCONS_SCORE: 0.8666

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R808W	TCGA-BT-A2LB	BLCA	TCGA	LRRPLAVLH	DEG_APCC_DBOX_1	0.0556
p.R808W	DO44098	BLCA	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	0.0556
p.P784L	TCGA-W3-AA1V	SKCM	TCGA	LRRPLAVLH	DEG_APCC_DBOX_1	0.1667
p.P784L	DO51276	SKCM	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	0.1667
p.R808L	DO45075	LINC	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	0.0556
p.P789S	DO229084	THCA	ICGC	LRRPLAVLH	DEG_APCC_DBOX_1	0.3056
p.R792S	SIDM00789	Colorectal Carcinoma	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	0.6316
p.R792S	ACH-000997	Colon/Colorectal Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	0.6316
p.R792S	ACH-001061	Colon/Colorectal Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	0.6316
p.L781I	SIDM00696	Non-Cancerous	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	0.0833
p.L781I	SIDM00772	Breast Carcinoma	GDSC	LRRPLAVLH	DEG_APCC_DBOX_1	0.0833
p.L781I	ACH-000755	Breast Cancer	CCLE	LRRPLAVLH	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AC6	Kinesin-like protein KIFC2	DEG_APCC_DBOX_1	790:798	LRRPLAVLH	APC,CDC20,FZR1	0.8356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons