DegronMD - Q96RE7(NACC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D273N	TCGA-A5-A0RA	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.D273N	DO42288	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.N353H	TCGA-AA-3815	COAD	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833
p.N353H	DO9924	COAD	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833
p.L343F	TCGA-D3-A2JG	SKCM	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation altering degron motif	0.6981
p.L343F	DO47613	SKCM	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation altering degron motif	0.6981
p.V326I	TCGA-DF-A2KN	UCEC	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.V326I	DO223282	UCEC	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.R331Q	TCGA-DI-A1BU	UCEC	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1944
p.R331Q	DO42023	UCEC	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1944
p.G352W	TCGA-EE-A29E	SKCM	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.G352W	DO37831	SKCM	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.R333H	TCGA-KB-A6F5	STAD	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.25
p.R333H	DO50128	STAD	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.25
p.A341V	DO228935	COCA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation altering degron motif	0.5825
p.R333L	DO229015	LICA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.25
p.R333C	DO222516	MELA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.25
p.A327V	SIDM00189	Melanoma	GDSC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833
p.A327V	ACH-002098	Skin Cancer	CCLE	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833
p.A327V	CP67-MEL	skin	COSMIC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833
p.P328T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.P328T	ACH-002256	Leukemia	CCLE	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.P328T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VRQDLASLP	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111

Kaplan plot for NACC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NACC1

UniProt ID: Q96RE7

Entrez ID: 112939

Protein name: Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NACC1 in