DegronMD

Uniprot ID: Q96RE7

Source protein: Nucleus accumbens-associated protein 1

Source gene: NACC1

Class: DEG_APCC_DBOX_1

Location: 336:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9314

ASA_SCORE: 75.3556

COIL: 0.6761

CONS_SCORE: 0.9536

DSS_SCORE: 0.3644

HELIX: 0.2481

FCONS_SCORE: 1.1888

RIG_SCORE: 0.7791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N353H	TCGA-AA-3815	COAD	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.0833
p.N353H	DO9924	COAD	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.0833
p.L343F	TCGA-D3-A2JG	SKCM	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.6981
p.L343F	DO47613	SKCM	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.6981
p.V326I	TCGA-DF-A2KN	UCEC	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.0556
p.V326I	DO223282	UCEC	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.0556
p.R331Q	TCGA-DI-A1BU	UCEC	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.1944
p.R331Q	DO42023	UCEC	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.1944
p.G352W	TCGA-EE-A29E	SKCM	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.1111
p.G352W	DO37831	SKCM	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.1111
p.R333H	TCGA-KB-A6F5	STAD	TCGA	VRQDLASLP	DEG_APCC_DBOX_1	0.25
p.R333H	DO50128	STAD	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.25
p.A341V	DO228935	COCA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.5825
p.R333L	DO229015	LICA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.25
p.R333C	DO222516	MELA	ICGC	VRQDLASLP	DEG_APCC_DBOX_1	0.25
p.A327V	SIDM00189	Melanoma	GDSC	VRQDLASLP	DEG_APCC_DBOX_1	0.0833
p.A327V	ACH-002098	Skin Cancer	CCLE	VRQDLASLP	DEG_APCC_DBOX_1	0.0833
p.A327V	CP67-MEL	skin	COSMIC	VRQDLASLP	DEG_APCC_DBOX_1	0.0833
p.P328T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRQDLASLP	DEG_APCC_DBOX_1	0.1111
p.P328T	ACH-002256	Leukemia	CCLE	VRQDLASLP	DEG_APCC_DBOX_1	0.1111
p.P328T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VRQDLASLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RE7	Nucleus accumbens-associated protein 1	DEG_APCC_DBOX_1	336:344	VRQDLASLP	APC,CDC20,FZR1	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons