DegronMD - Q8TDZ2(MICAL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E775D	TCGA-D7-A6EY	STAD	TCGA	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1389
p.E775D	DO50118	STAD	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1389
p.Q639H	TCGA-DA-A1IB	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.0833
p.A792V	TCGA-DU-6392	LGG	TCGA	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.2222
p.A792V	DO22237	LGG	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.2222
p.A792V	DO232224	PBCA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.2222
p.A792V	ACH-002222	Leukemia	CCLE	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.2222
p.A792V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.2222
p.S625F	TCGA-GN-A266	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation blocking phosphorylation signal	0.75
p.S774R	TCGA-LN-A49Y	ESCA	TCGA	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1111
p.G619C	TCGA-RD-A8NB	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1389
p.I620S	DO48386	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1667
p.I620S	DO229013	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1667
p.F626L	DO219093	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6981
p.E782Q	DO228972	LICA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation altering degron motif	0.6744
p.N627K	DO229041	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6918
p.E795D	DO222434	MELA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1389
p.E795D	DO37851	SKCM	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1389
p.V795F	DO229146	NKTL	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1389
p.G638C	DO50142	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1111
p.Q774L	DO229216	THCA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	782:788	Mutation rewiring degron network	0.1111
p.S628G	SIDM00333	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6993
p.S628G	MFE-319	endometrium	COSMIC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6993
p.V632E	ACH-000819	Brain Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.2778
p.V632E	LN-18	central nervous system	COSMIC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.2778
p.A624T	ACH-000939	Sarcoma	CCLE	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.2778
p.A624T	SK-UT-1	soft tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.2778
p.C638Y	MDA-MB-361	breast	COSMIC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1111
p.H639N	MDA-MB-361	breast	COSMIC	PGTSS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.0833

Kaplan plot for MICAL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MICAL1

UniProt ID: Q8TDZ2

Entrez ID: 64780

Protein name: [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MICAL1 in