DegronMD

Uniprot ID: Q8TDZ2

Source protein: [F-actin]-monooxygenase MICAL1

Source gene: MICAL1

Class: DEG_SCF_FBW7_1

Location: 782:788

E3 ligase: FBXW7

DEGRON score: 0.9022

ASA_SCORE: 74.4857

COIL: 0.8666

CONS_SCORE: 0.3252

DSS_SCORE: 0.8856

HELIX: 0.1103

FCONS_SCORE: 1.0018

RIG_SCORE: 0.5349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E775D	TCGA-D7-A6EY	STAD	TCGA	LSTPTAS	DEG_SCF_FBW7_1	0.1389
p.E775D	DO50118	STAD	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.1389
p.A792V	TCGA-DU-6392	LGG	TCGA	LSTPTAS	DEG_SCF_FBW7_1	0.2222
p.A792V	DO22237	LGG	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.2222
p.A792V	DO232224	PBCA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.2222
p.A792V	ACH-002222	Leukemia	CCLE	LSTPTAS	DEG_SCF_FBW7_1	0.2222
p.A792V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTAS	DEG_SCF_FBW7_1	0.2222
p.S774R	TCGA-LN-A49Y	ESCA	TCGA	LSTPTAS	DEG_SCF_FBW7_1	0.1111
p.E782Q	DO228972	LICA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.6744
p.E795D	DO222434	MELA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.1389
p.E795D	DO37851	SKCM	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.1389
p.V795F	DO229146	NKTL	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.1389
p.Q774L	DO229216	THCA	ICGC	LSTPTAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SCF_FBW7_1	782:788	LSTPTAS	FBXW7	0.9022	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons