DegronMD

Uniprot ID: Q7L014

Source protein: Probable ATP-dependent RNA helicase DDX46

Source gene: DDX46

Class: DEG_APCC_DBOX_1

Location: 314:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9988

ASA_SCORE: 90.4444

COIL: 0.7812

CONS_SCORE: 0.4846

DSS_SCORE: 0.3787

HELIX: 0.1341

FCONS_SCORE: 1.0512

RIG_SCORE: 0.7796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A306T	TCGA-B5-A11E	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.1111
p.A306T	DO41644	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.1111
p.G309W	TCGA-D3-A3CE	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.1944
p.G309W	DO37405	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.1944
p.T305A	TCGA-DF-A2KU	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.5278
p.T305A	DO223286	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.5278
p.Q311E	TCGA-E7-A7DV	BLCA	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.25
p.Q311E	TCGA-MV-A51V	BLCA	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.25
p.Q311E	DO48583	BLCA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.25
p.Q311E	DO474	BLCA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.25
p.E319K	TCGA-EE-A2GB	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.591
p.E319K	DO222683	MELA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.591
p.E319K	DO37417	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.591
p.K325T	TCGA-FI-A2D5	UCEC	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.6944
p.K325T	DO41331	UCEC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.6944
p.H323Y	TCGA-GF-A6C9	SKCM	TCGA	QRKLLEPVD	DEG_APCC_DBOX_1	0.3056
p.H323Y	DO51254	SKCM	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.3056
p.Q314H	DO229035	LICA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.647
p.R332S	DO229038	LICA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.0556
p.I326M	DO23376	LINC	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.2222
p.E327K	DO222572	MELA	ICGC	QRKLLEPVD	DEG_APCC_DBOX_1	0.1944
p.R315Q	SIDM00193	Colorectal Carcinoma	GDSC	QRKLLEPVD	DEG_APCC_DBOX_1	0.7329
p.R315Q	ACH-000991	Colon/Colorectal Cancer	CCLE	QRKLLEPVD	DEG_APCC_DBOX_1	0.7329
p.R315Q	SNU-81	large_intestine	COSMIC	QRKLLEPVD	DEG_APCC_DBOX_1	0.7329
p.L317P	SIDM00469	Pancreatic Carcinoma	GDSC	QRKLLEPVD	DEG_APCC_DBOX_1	0.6471
p.L317P	ACH-000320	Pancreatic Cancer	CCLE	QRKLLEPVD	DEG_APCC_DBOX_1	0.6471
p.L317P	PSN1	pancreas	COSMIC	QRKLLEPVD	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_APCC_DBOX_1	314:322	QRKLLEPVD	APC,CDC20,FZR1	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRKLLEPVD

Degron related mutations and impact score

Drug responses associated with DDX46 mutations

All proteins holding degron of QRKLLEPVD