DegronMD

Uniprot ID: Q6RI45

Source protein: Bromodomain and WD repeat-containing protein 3

Source gene: BRWD3

Class: DEG_SPOP_SBC_1

Location: 1489:1493

E3 ligase: SPOP

DEGRON score: 0.9579

ASA_SCORE: 103.12

COIL: 0.9502

CONS_SCORE: 0.2931

DSS_SCORE: 0.6345

HELIX: 0.04

FCONS_SCORE: 1.0318

RIG_SCORE: 0.5991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1489S	TCGA-49-4514	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.7588
p.A1489S	DO23818	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7588
p.R1490M	TCGA-53-7624	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.7521
p.R1490M	DO25058	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7521
p.H1488Y	TCGA-60-2698	LUSC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.3056
p.H1488Y	DO26469	LUSC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.A1503S	TCGA-64-5775	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.0556
p.A1503S	DO26025	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.S1493Y	TCGA-QG-A5YV	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.712
p.S1493Y	DO44088	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.712
p.A1503D	DO229031	LICA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.0556
p.Q1482H	SIDM00057	Neuroblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.Q1482H	ACH-000676	Brain Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.1389
p.Q1482H	ACH-002389	Neuroblastoma	CCLE	ARTSS	DEG_SPOP_SBC_1	0.1389
p.Q1482H	ACN	autonomic_ganglia	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.S1500L	SIDM00560	Gastric Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.S1500L	ACH-000678	Gastric Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.1389
p.S1500L	MKN7	stomach	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.V1486L	SIDM01561	Melanoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.25
p.V1486L	ACH-000799	Skin Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons