DegronMD

Uniprot ID: Q5SQN1

Source protein: Synaptosomal-associated protein 47

Source gene: SNAP47

Class: DEG_SPOP_SBC_1

Location: 359:363

E3 ligase: SPOP

DEGRON score: 0.8489

ASA_SCORE: 86.64

COIL: 0.8386

CONS_SCORE: 0.3454

DSS_SCORE: 0.2954

HELIX: 0.141

FCONS_SCORE: 0.8432

RIG_SCORE: 0.6823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R360I	TCGA-06-5416	GBM	TCGA	ARTSS	DEG_SPOP_SBC_1	0.6991
p.E351Q	TCGA-55-7995	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1111
p.A365T	TCGA-AG-A002	READ	TCGA	ARTSS	DEG_SPOP_SBC_1	0.2778
p.S358N	SIDM00607	Glioblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S358N	SIDM00380	Acute Myeloid Leukemia	GDSC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S358N	ACH-000373	Leukemia	CCLE	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S358N	ACH-000622	Brain Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S358N	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S358N	KNS-42	central_nervous_system	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.3056
p.S362C	SIDM00767	Small Cell Lung Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.7541
p.S362C	ACH-001136	Lung Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.7541
p.S362C	NCI-H187	lung	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.7541
p.R357K	SIDM00150	Colorectal Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.R357K	ACH-000969	Colon/Colorectal Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.2778
p.R357K	KM12	large_intestine	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.S357R	NCI-SNU-5	stomach	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons