DegronMD

Uniprot ID: A1L170

Source protein: Uncharacterized protein C1orf226

Source gene: C1orf226

Class: DEG_SPOP_SBC_1

Location: 254:258

E3 ligase: SPOP

DEGRON score: 0.6742

ASA_SCORE: 85.04

COIL: 0.841

CONS_SCORE: 0.3176

DSS_SCORE: 0.8264

HELIX: 0.0602

FCONS_SCORE: 0.7114

RIG_SCORE: 0.6029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R263K	TCGA-BF-AAP4	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1944
p.P267H	TCGA-CV-6937	HNSC	TCGA	ARTSS	DEG_SPOP_SBC_1	0.0833
p.E253K	TCGA-DA-A1I1	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	0.3056
p.A264V	TCGA-F4-6570	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	0.1667
p.D267N	DO233694	GACA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.0833
p.A254V	DO22851	LIHC	ICGC	ARTSS	DEG_SPOP_SBC_1	0.5825
p.R255L	DO25058	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7316
p.P266Q	DO37835	SKCM	ICGC	ARTSS	DEG_SPOP_SBC_1	0.1111
p.D260N	DO47925	STAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.A254T	ACH-000801	Skin Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.7139
p.S257Y	ACH-000979	Prostate Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons