DegronMD

Uniprot ID: O96028

Source protein: Histone-lysine N-methyltransferase NSD2

Source gene: NSD2

Class: DEG_SPOP_SBC_1

Location: 567:571

E3 ligase: SPOP

DEGRON score: 0.9591

ASA_SCORE: 87.38

COIL: 0.6104

CONS_SCORE: 0.2822

DSS_SCORE: 0.5121

HELIX: 0.3706

FCONS_SCORE: 1.0113

RIG_SCORE: 0.7271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D560E	SIDM00845	Burkitt's Lymphoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.D560H	SIDM01233	Colorectal Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.D560H	C2BBe1	large_intestine	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.1389
p.K573T	SIDM01611	Endometrial Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.M575I	SIDM01519	Head and Neck Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.2222
p.R575Q	ESS-1	endometrium	COSMIC	ARTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons