DegronMD

Uniprot ID: P48552

Source protein: Nuclear receptor-interacting protein 1

Source gene: NRIP1

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.9627

ASA_SCORE: 87

COIL: 0.9162

CONS_SCORE: 0.47

DSS_SCORE: 0.5895

HELIX: 0.061

FCONS_SCORE: 1.0437

RIG_SCORE: 0.6572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S333P	TCGA-BH-A1FU	BRCA	TCGA	ARTSS	DEG_SPOP_SBC_1	0.6752
p.S333P	DO6128	BRCA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.6752
p.S333L	DO50383	ESAD	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7667
p.G327S	DO233903	GACA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.2778
p.L325F	DO222702	MELA	ICGC	ARTSS	DEG_SPOP_SBC_1	0.2222
p.S332L	DO46571	OV	ICGC	ARTSS	DEG_SPOP_SBC_1	0.7667
p.N326K	SIDM00760	Small Cell Lung Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	0.25
p.S339N	ACH-001456	Colon/Colorectal Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96028	Histone-lysine N-methyltransferase NSD2	DEG_SPOP_SBC_1	567:571	ARTSS	SPOP	0.9591	More...
P48552	Nuclear receptor-interacting protein 1	DEG_SPOP_SBC_1	329:333	ARTSS	SPOP	0.9627	More...
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	17:21	ARTSS	SPOP	0.9986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2375:2379	ARTSS	SPOP	0.8756	More...
Q5SQN1	Synaptosomal-associated protein 47	DEG_SPOP_SBC_1	359:363	ARTSS	SPOP	0.8489	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1489:1493	ARTSS	SPOP	0.9579	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	423:427	ARTSS	SPOP	0.9838	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	185:189	ARTSS	SPOP	0.9422	More...
A1L170	Uncharacterized protein C1orf226	DEG_SPOP_SBC_1	254:258	ARTSS	SPOP	0.6742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons