DegronMD - Q5SQN1(SNAP47)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R360I	TCGA-06-5416	GBM	TCGA	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.6991
p.E351Q	TCGA-55-7995	LUAD	TCGA	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1111
p.A365T	TCGA-AG-A002	READ	TCGA	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.S225N	TCGA-BH-A0HK	BRCA	TCGA	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.25
p.S225N	DO5717	BRCA	ICGC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.25
p.P219S	TCGA-EO-A22U	UCEC	TCGA	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.0833
p.P219S	DO43755	UCEC	ICGC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.0833
p.P223S	SIDM00334	Endometrial Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1944
p.P223S	ACH-000879	Endometrial/Uterine Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1944
p.P223S	MFE-296	endometrium	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1944
p.S358N	SIDM00607	Glioblastoma	GDSC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.S358N	SIDM00380	Acute Myeloid Leukemia	GDSC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.S358N	ACH-000373	Leukemia	CCLE	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.S358N	ACH-000622	Brain Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.S358N	SKM-1	haematopoietic and lymphoid tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.S358N	KNS-42	central nervous system	COSMIC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.3056
p.P233L	SIDM00317	Kidney Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.6471
p.P233L	ACH-000171	Kidney Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.6471
p.P233L	VMRC-RCZ	kidney	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.6471
p.S362C	SIDM00767	Small Cell Lung Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7541
p.S362C	ACH-001136	Lung Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7541
p.S362C	NCI-H187	lung	COSMIC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7541
p.M243I	SIDM00146	Breast Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1111
p.M243I	ACH-000768	Breast Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1111
p.M243I	MDA-MB-231	breast	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1111
p.R357K	SIDM00150	Colorectal Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.R357K	ACH-000969	Colon/Colorectal Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.R357K	KM12	large intestine	COSMIC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.M218I	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.0556
p.R220K	NCI-H2347	lung	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1111
p.S357R	NCI-SNU-5	stomach	COSMIC	ARTSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.V234L	EBC-1	lung	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.6765

Kaplan plot for SNAP47 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNAP47

UniProt ID: Q5SQN1

Entrez ID: 116841

Protein name: Synaptosomal-associated protein 47 (SNAP-47) (Epididymis luminal protein 170) (Synaptosomal-associated 47 kDa protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNAP47 in