DegronMD

Uniprot ID: Q5SQN1

Source protein: Synaptosomal-associated protein 47

Source gene: SNAP47

Class: DEG_SCF_FBW7_1

Location: 228:235

E3 ligase: FBXW7

DEGRON score: 0.9228

ASA_SCORE: 86.5625

COIL: 0.8488

CONS_SCORE: 0.4084

DSS_SCORE: 0.454

HELIX: 0.0456

FCONS_SCORE: 0.9858

RIG_SCORE: 0.7046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S225N	TCGA-BH-A0HK	BRCA	TCGA	LWKTPPET	DEG_SCF_FBW7_1	0.25
p.S225N	DO5717	BRCA	ICGC	LWKTPPET	DEG_SCF_FBW7_1	0.25
p.P219S	TCGA-EO-A22U	UCEC	TCGA	LWKTPPET	DEG_SCF_FBW7_1	0.0833
p.P219S	DO43755	UCEC	ICGC	LWKTPPET	DEG_SCF_FBW7_1	0.0833
p.P223S	SIDM00334	Endometrial Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	0.1944
p.P223S	ACH-000879	Endometrial/Uterine Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	0.1944
p.P223S	MFE-296	endometrium	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.1944
p.P233L	SIDM00317	Kidney Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	0.6471
p.P233L	ACH-000171	Kidney Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	0.6471
p.P233L	VMRC-RCZ	kidney	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.6471
p.M243I	SIDM00146	Breast Carcinoma	GDSC	LWKTPPET	DEG_SCF_FBW7_1	0.1111
p.M243I	ACH-000768	Breast Cancer	CCLE	LWKTPPET	DEG_SCF_FBW7_1	0.1111
p.M243I	MDA-MB-231	breast	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.1111
p.M218I	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.0556
p.R220K	NCI-H2347	lung	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.1111
p.V234L	EBC-1	lung	COSMIC	LWKTPPET	DEG_SCF_FBW7_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SQN1	Synaptosomal-associated protein 47	DEG_SCF_FBW7_1	228:235	LWKTPPET	FBXW7	0.9228	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons