DegronMD - P48552(NRIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P411T	TCGA-27-2518	GBM	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.2222
p.P411T	DO13773	GBM	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.2222
p.M393I	TCGA-63-A5MG	LUSC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1111
p.M393I	DO52019	LUSC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1111
p.S333P	TCGA-BH-A1FU	BRCA	TCGA	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.6752
p.S333P	DO6128	BRCA	ICGC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.6752
p.K850N	TCGA-BK-A6W3	UCEC	TCGA	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation substituting flanking lysine	0.2222
p.K850N	DO50076	UCEC	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation substituting flanking lysine	0.2222
p.K850N	SIDM01611	Endometrial Carcinoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation substituting flanking lysine	0.2222
p.K850N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation substituting flanking lysine	0.2222
p.S403R	TCGA-BS-A0UV	UCEC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation altering degron motif	0.6316
p.S403R	DO42793	UCEC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation altering degron motif	0.6316
p.P869Q	TCGA-CA-6717	COAD	TCGA	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.1944
p.P869Q	DO8264	COAD	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.1944
p.D477Y	TCGA-CV-A45W	HNSC	TCGA	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.7325
p.D477Y	DO52060	HNSC	ICGC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.7325
p.T413N	TCGA-EO-A22X	UCEC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1667
p.T413N	DO43907	UCEC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1667
p.Q484E	TCGA-F7-A50J	HNSC	TCGA	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.1667
p.Q484E	DO44431	HNSC	ICGC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.1667
p.P856H	DO230336	COCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.2778
p.S333L	DO50383	ESAD	ICGC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7667
p.Y862H	DO48320	ESCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation altering degron motif	0.7229
p.S487T	DO233153	GACA	ICGC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.0833
p.L467S	DO233898	GACA	ICGC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.25
p.G327S	DO233903	GACA	ICGC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.E848V	DO228380	LICA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.0556
p.P392T	DO229022	LICA	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.0833
p.R401S	DO231658	LINC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	401:407	Mutation altering degron motif	0.7427
p.L325F	DO222702	MELA	ICGC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.S849L	DO222868	MELA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.0833
p.D477N	DO222837	MELA	ICGC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.6932
p.S332L	DO46571	OV	ICGC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7667
p.K860E	DO48967	PBCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation altering degron motif	0.591
p.W471C	SIDM01151	Hepatocellular Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.5889
p.W471C	SIDM00923	Cervical Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.5889
p.W471C	ACH-001336	Cervical Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.5889
p.W471C	Ca-Ski	cervix	COSMIC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.5889
p.W471C	SNU-182	liver	COSMIC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation altering degron motif	0.5889
p.K488N	SIDM00193	Colorectal Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation substituting flanking lysine	0.1667
p.K488N	ACH-000991	Colon/Colorectal Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	470:478	Mutation substituting flanking lysine	0.1667
p.K488N	SNU-81	large intestine	COSMIC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation substituting flanking lysine	0.1667
p.M873I	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.0833
p.M873I	ACH-002215	Lymphoma	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.0833
p.M873I	BC-3	haematopoietic and lymphoid tissue	COSMIC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.0833
p.N469S	SIDM00797	Melanoma	GDSC	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.3056
p.F870L	SIDM00814	Other Solid Cancers	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.1667
p.E867Q	SIDM01042	Breast Carcinoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.25
p.E867Q	ACH-001065	Breast Cancer	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.25
p.E867Q	EVSA-T	breast	COSMIC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	858:864	Mutation rewiring degron network	0.25
p.N326K	SIDM00760	Small Cell Lung Carcinoma	GDSC	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.25
p.N462K	ACH-000272	Kidney Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	470:478	Mutation rewiring degron network	0.1111
p.S339N	ACH-001456	Colon/Colorectal Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667

Kaplan plot for NRIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRIP1

UniProt ID: P48552

Entrez ID: 8204

Protein name: Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRIP1 in