DegronMD

Uniprot ID: P48552

Source protein: Nuclear receptor-interacting protein 1

Source gene: NRIP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 401:407

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9365

ASA_SCORE: 102.6

COIL: 0.9219

CONS_SCORE: 0.5308

DSS_SCORE: 0.6805

HELIX: 0.0447

FCONS_SCORE: 0.8901

RIG_SCORE: 0.6273

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R401S	DO231658	LINC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.7427
p.S403R	TCGA-BS-A0UV	UCEC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.6316
p.S403R	DO42793	UCEC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.6316
p.P411T	TCGA-27-2518	GBM	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P411T	DO13773	GBM	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T413N	TCGA-EO-A22X	UCEC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T413N	DO43907	UCEC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.M393I	TCGA-63-A5MG	LUSC	TCGA	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.M393I	DO52019	LUSC	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P392T	DO229022	LICA	ICGC	RGSIFEE	LIG_APCC_ABBAyCdc20_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48552	Nuclear receptor-interacting protein 1	LIG_APCC_ABBAyCdc20_2	401:407	RGSIFEE	APC,CDC20,FZR1	0.9365	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons