DegronMD

Uniprot ID: P48552

Source protein: Nuclear receptor-interacting protein 1

Source gene: NRIP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 858:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9988

ASA_SCORE: 119.6

COIL: 0.9176

CONS_SCORE: 0.6901

DSS_SCORE: 0.3865

HELIX: 0.0431

FCONS_SCORE: 1.3635

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K850N	TCGA-BK-A6W3	UCEC	TCGA	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K850N	DO50076	UCEC	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K850N	SIDM01611	Endometrial Carcinoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K850N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P869Q	TCGA-CA-6717	COAD	TCGA	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P869Q	DO8264	COAD	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P856H	DO230336	COCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Y862H	DO48320	ESCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.7229
p.E848V	DO228380	LICA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S849L	DO222868	MELA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K860E	DO48967	PBCA	ICGC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.591
p.M873I	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M873I	ACH-002215	Lymphoma	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M873I	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.F870L	SIDM00814	Other Solid Cancers	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E867Q	SIDM01042	Breast Carcinoma	GDSC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E867Q	ACH-001065	Breast Cancer	CCLE	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E867Q	EVSA-T	breast	COSMIC	KRKLYTE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48552	Nuclear receptor-interacting protein 1	LIG_APCC_ABBAyCdc20_2	858:864	KRKLYTE	APC,CDC20,FZR1	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons