DegronMD

Uniprot ID: P48552

Source protein: Nuclear receptor-interacting protein 1

Source gene: NRIP1

Class: DEG_COP1_1

Location: 470:478

E3 ligase: COP1

DEGRON score: 0.6383

ASA_SCORE: 92.2333

COIL: 0.9272

CONS_SCORE: 0.6579

DSS_SCORE: 0.4405

HELIX: 0.0443

FCONS_SCORE: 1.0534

RIG_SCORE: 0.7645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D477Y	TCGA-CV-A45W	HNSC	TCGA	TWDPKVPDV	DEG_COP1_1	0.7325
p.D477Y	DO52060	HNSC	ICGC	TWDPKVPDV	DEG_COP1_1	0.7325
p.Q484E	TCGA-F7-A50J	HNSC	TCGA	TWDPKVPDV	DEG_COP1_1	0.1667
p.Q484E	DO44431	HNSC	ICGC	TWDPKVPDV	DEG_COP1_1	0.1667
p.S487T	DO233153	GACA	ICGC	TWDPKVPDV	DEG_COP1_1	0.0833
p.L467S	DO233898	GACA	ICGC	TWDPKVPDV	DEG_COP1_1	0.25
p.D477N	DO222837	MELA	ICGC	TWDPKVPDV	DEG_COP1_1	0.6932
p.W471C	SIDM01151	Hepatocellular Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	0.5889
p.W471C	SIDM00923	Cervical Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	0.5889
p.W471C	ACH-001336	Cervical Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	0.5889
p.W471C	Ca-Ski	cervix	COSMIC	TWDPKVPDV	DEG_COP1_1	0.5889
p.W471C	SNU-182	liver	COSMIC	TWDPKVPDV	DEG_COP1_1	0.5889
p.K488N	SIDM00193	Colorectal Carcinoma	GDSC	TWDPKVPDV	DEG_COP1_1	0.1667
p.K488N	ACH-000991	Colon/Colorectal Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	0.1667
p.K488N	SNU-81	large_intestine	COSMIC	TWDPKVPDV	DEG_COP1_1	0.1667
p.N469S	SIDM00797	Melanoma	GDSC	TWDPKVPDV	DEG_COP1_1	0.3056
p.N462K	ACH-000272	Kidney Cancer	CCLE	TWDPKVPDV	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48552	Nuclear receptor-interacting protein 1	DEG_COP1_1	470:478	TWDPKVPDV	COP1	0.6383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons