DegronMD - A1L170(C1orf226)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q185H	TCGA-73-4670	LUAD	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.0833
p.L188I	TCGA-AA-A00N	COAD	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation substituting flanking lysine	0.2778
p.S189I	TCGA-B5-A1MX	UCEC	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.1944
p.R263K	TCGA-BF-AAP4	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1944
p.P267H	TCGA-CV-6937	HNSC	TCGA	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.E253K	TCGA-DA-A1I1	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.3056
p.G194R	TCGA-DA-A3F5	SKCM	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation altering degron motif	0.7568
p.A206T	TCGA-E6-A1LX	UCEC	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.2222
p.S198L	TCGA-EE-A3AC	SKCM	TCGA	EVSLSVPDL	DEG_COP1_1	194:202	Mutation altering degron motif	0.7667
p.A264V	TCGA-F4-6570	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1667
p.E184K	DO218176	BRCA	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.0556
p.K205E	DO229013	COCA	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation substituting flanking lysine	0.3611
p.D206Y	DO52502	EOPC	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.2222
p.D267N	DO233694	GACA	ICGC	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.A254V	DO22851	LIHC	ICGC	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.5825
p.R255L	DO25058	LUAD	ICGC	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.7316
p.S196F	DO222527	MELA	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation altering degron motif	0.7982
p.P266Q	DO37835	SKCM	ICGC	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.E210K	DO37966	SKCM	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.1111
p.D260N	DO47925	STAD	ICGC	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.2778
p.V195L	DO41494	UCEC	ICGC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation altering degron motif	0.5654
p.S184L	SIDM00499	Prostate Carcinoma	GDSC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation rewiring degron network	0.0556
p.P199L	SIDM00679	Cervical Carcinoma	GDSC	EVSLSVPDL	DEG_COP1_1	194:202	Mutation altering degron motif	0.7582
p.A254T	ACH-000801	Skin Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.7139
p.S257Y	ACH-000979	Prostate Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf226

UniProt ID: A1L170

Entrez ID: 400793

Protein name: Uncharacterized protein C1orf226

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf226 in